Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
Ansari, Hifzur Rahman
Otto, Thomas D.
Linger, Christen M K
Olisko, Martin K.
Del Campo, Javier
Gornik, Sebastian G.
Katris, Nicholas J.
Mast, Fred D.
Panigrahi, Aswini Kumar
Rawlings, Neil D.
Padron Regalado, Eriko
Neafsey, Daniel E.
Keeling, Patrick J.
Roos, David S.
Dacks, Joel B.
Templeton, Thomas J.
Waller, Ross F.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Bioscience Core Lab
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Pathogen Genomics Laboratory
Permanent link to this recordhttp://hdl.handle.net/10754/565962
MetadataShow full item record
AbstractThe eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.
PublishereLife Sciences Organisation, Ltd.
- The Organellar Genomes of Chromera and Vitrella, the Phototrophic Relatives of Apicomplexan Parasites.
- Authors: Oborník M, Lukeš J
- Issue date: 2015
- Sterol Composition and Biosynthetic Genes of Vitrella brassicaformis, a Recently Discovered Chromerid: Comparison to Chromera velia and Phylogenetic Relationship with Apicomplexan Parasites.
- Authors: Khadka M, Salem M, Leblond JD
- Issue date: 2015 Nov-Dec
- Chromera velia: The Missing Link in the Evolution of Parasitism.
- Authors: Weatherby K, Carter D
- Issue date: 2013
- Evolution of chloroplast transcript processing in Plasmodium and its chromerid algal relatives.
- Authors: Dorrell RG, Drew J, Nisbet RE, Howe CJ
- Issue date: 2014 Jan
- Separation and identification of lipids in the photosynthetic cousins of Apicomplexa Chromera velia and Vitrella brassicaformis.
- Authors: Tomčala A, Kyselová V, Schneedorferová I, Opekarová I, Moos M, Urajová P, Kručinská J, Oborník M
- Issue date: 2017 Sep