Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
Type
ArticleAuthors
Woo, YongAnsari, Hifzur Rahman

Otto, Thomas D.
Linger, Christen M K
Olisko, Martin K.
Michálek, Jan
Saxena, Alka
Shanmugam, Dhanasekaran

Tayyrov, Annageldi
Veluchamy, Alaguraj

Ali, Shahjahan
Bernal, Axel
Del Campo, Javier
Cihlář, Jaromír
Flegontov, Pavel
Gornik, Sebastian G.
Hajdušková, Eva
Horák, Aleš
Janouškovec, Jan
Katris, Nicholas J.
Mast, Fred D.
Miranda-Saavedra, Diego
Mourier, Tobias
Naeem, Raeece

Nair, Mridul
Panigrahi, Aswini Kumar
Rawlings, Neil D.
Padron Regalado, Eriko
Ramaprasad, Abhinay

Samad, Nadira
Tomčala, Aleš
Wilkes, Jon
Neafsey, Daniel E.
Doerig, Christian
Bowler, Chris
Keeling, Patrick J.
Roos, David S.
Dacks, Joel B.
Templeton, Thomas J.
Waller, Ross F.
Lukeš, Julius
Oborník, Miroslav
Pain, Arnab

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Core Lab
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Bioscience Program
Pathogen Genomics Laboratory
Core Labs
Date
2015-07-14Permanent link to this record
http://hdl.handle.net/10754/565962
Metadata
Show full item recordAbstract
The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.Citation
Woo, Y. H., Ansari, H., Otto, T. D., Klinger, C. M., Kolisko, M., Michálek, J., … Pain, A. (2015). Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. eLife, 4. doi:10.7554/elife.06974Publisher
eLife Sciences Publications, LtdJournal
eLifePubMed ID
26175406Additional Links
http://europepmc.org/articles/pmc4501334?pdf=renderae974a485f413a2113503eed53cd6c53
10.7554/eLife.06974
Scopus Count
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