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dc.contributor.authorSagar, Sunil
dc.contributor.authorKaur, Mandeep
dc.contributor.authorMinneman, Kenneth P.
dc.contributor.authorBajic, Vladimir B.
dc.date.accessioned2015-08-12T08:56:42Z
dc.date.available2015-08-12T08:56:42Z
dc.date.issued2010-09
dc.identifier.citationSagar, S., Kaur, M., Minneman, K. P., & Bajic, V. B. (2010). Anti-cancer activities of diospyrin, its derivatives and analogues. European Journal of Medicinal Chemistry, 45(9), 3519–3530. doi:10.1016/j.ejmech.2010.06.021
dc.identifier.issn02235234
dc.identifier.pmid20615584
dc.identifier.doi10.1016/j.ejmech.2010.06.021
dc.identifier.urihttp://hdl.handle.net/10754/565955
dc.description.abstractNatural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.
dc.publisherElsevier BV
dc.subjectAnti-cancer
dc.subjectApoptosis
dc.subjectDiospyrin
dc.subjectQuinone
dc.subjectReactive oxygen species
dc.titleAnti-cancer activities of diospyrin, its derivatives and analogues
dc.typeArticle
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalEuropean Journal of Medicinal Chemistry
kaust.personSagar, Sunil
kaust.personKaur, Mandeep
kaust.personBajic, Vladimir B.
kaust.personMinneman, Kenneth P.


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