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    Anti-cancer activities of diospyrin, its derivatives and analogues

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    Type
    Article
    Authors
    Sagar, Sunil
    Kaur, Mandeep
    Minneman, Kenneth P.
    Bajic, Vladimir B. cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Computational Bioscience Research Center (CBRC)
    Applied Mathematics and Computational Science Program
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2010-09
    Permanent link to this record
    http://hdl.handle.net/10754/565955
    
    Metadata
    Show full item record
    Abstract
    Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.
    Citation
    Sagar, S., Kaur, M., Minneman, K. P., & Bajic, V. B. (2010). Anti-cancer activities of diospyrin, its derivatives and analogues. European Journal of Medicinal Chemistry, 45(9), 3519–3530. doi:10.1016/j.ejmech.2010.06.021
    Publisher
    Elsevier BV
    Journal
    European Journal of Medicinal Chemistry
    DOI
    10.1016/j.ejmech.2010.06.021
    PubMed ID
    20615584
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejmech.2010.06.021
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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