Anti-cancer activities of diospyrin, its derivatives and analogues
Type
ArticleKAUST Department
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) DivisionComputational Bioscience Research Center (CBRC)
Applied Mathematics and Computational Science Program
Biological and Environmental Sciences and Engineering (BESE) Division
Date
2010-09Permanent link to this record
http://hdl.handle.net/10754/565955
Metadata
Show full item recordAbstract
Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.Citation
Sagar, S., Kaur, M., Minneman, K. P., & Bajic, V. B. (2010). Anti-cancer activities of diospyrin, its derivatives and analogues. European Journal of Medicinal Chemistry, 45(9), 3519–3530. doi:10.1016/j.ejmech.2010.06.021Publisher
Elsevier BVPubMed ID
20615584ae974a485f413a2113503eed53cd6c53
10.1016/j.ejmech.2010.06.021