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dc.contributor.authorJin, Hailing
dc.contributor.authorZhu, Jian-Kang
dc.date.accessioned2015-08-12T08:56:25Z
dc.date.available2015-08-12T08:56:25Z
dc.date.issued2010-05-03
dc.identifier.issn08909369
dc.identifier.pmid20439425
dc.identifier.doi10.1101/gad.1927310
dc.identifier.urihttp://hdl.handle.net/10754/565949
dc.description.abstractRNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
dc.description.sponsorshipThe work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.
dc.publisherCold Spring Harbor Laboratory
dc.subjectArgonaute
dc.subjectGW motif
dc.subjectTCV
dc.subjectViral suppressor
dc.titleA viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
dc.typeArticle
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalGenes & Development
dc.identifier.pmcidPMC2861183
dc.contributor.institutionInstitute for Integrative Genome Biology, University of California at Riverside, Riverside, CA 92521, United States
dc.contributor.institutionDepartment of Plant Pathology and Microbiology, University of California at Riverside, Riverside, CA 92521, United States
dc.contributor.institutionDepartment of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, United States
kaust.personZhu, Jian-Kang
dc.date.published-online2010-05-03
dc.date.published-print2010-05-01


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