A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
KAUST DepartmentDesert Agriculture Initiative
Biological and Environmental Sciences and Engineering (BESE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/565949
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AbstractRNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
SponsorsThe work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.
PublisherCold Spring Harbor Laboratory
JournalGenes & Development
PubMed Central IDPMC2861183
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