A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
KAUST DepartmentDesert Agriculture Initiative
Biological and Environmental Sciences and Engineering (BESE) Division
MetadataShow full item record
AbstractRNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
SponsorsThe work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.
PublisherCold Spring Harbor Laboratory Press
JournalGenes & Development
PubMed Central IDPMC2861183
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