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    A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes

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    Type
    Article
    Authors
    Jin, Hailing
    Zhu, Jian-Kang cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Center for Desert Agriculture
    Date
    2010-05-03
    Online Publication Date
    2010-05-03
    Print Publication Date
    2010-05-01
    Permanent link to this record
    http://hdl.handle.net/10754/565949
    
    Metadata
    Show full item record
    Abstract
    RNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
    Citation
    Jin, H., & Zhu, J. K. (2010). A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes. Genes & Development, 24(9), 853–856. doi:10.1101/gad.1927310
    Sponsors
    The work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.
    Publisher
    Cold Spring Harbor Laboratory
    Journal
    Genes & Development
    DOI
    10.1101/gad.1927310
    PubMed ID
    20439425
    PubMed Central ID
    PMC2861183
    ae974a485f413a2113503eed53cd6c53
    10.1101/gad.1927310
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Center for Desert Agriculture

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