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dc.contributor.authorWang, Jim Jing-Yan
dc.contributor.authorGao, Xin
dc.date.accessioned2015-08-11T13:43:10Z
dc.date.available2015-08-11T13:43:10Z
dc.date.issued2014-12
dc.identifier.doi10.1109/ICDMW.2014.142
dc.identifier.urihttp://hdl.handle.net/10754/565847
dc.description.abstractTrypanosma brucei (T. Brucei) is an important pathogen agent of African trypanosomiasis. The flagellum is an essential and multifunctional organelle of T. Brucei, thus it is very important to recognize the flagellar proteins from T. Brucei proteins for the purposes of both biological research and drug design. In this paper, we investigate computationally recognizing flagellar proteins in T. Brucei by pattern recognition methods. It is argued that an optimal decision function can be obtained as the difference of probability functions of flagella protein and the non-flagellar protein for the purpose of flagella protein recognition. We propose to learn a multi-kernel classification function to approximate this optimal decision function, by minimizing the information loss of such approximation which is measured by the Kull back-Leibler (KL) divergence. An iterative multi-kernel classifier learning algorithm is developed to minimize the KL divergence for the problem of T. Brucei flagella protein recognition, experiments show its advantage over other T. Brucei flagellar protein recognition and multi-kernel learning methods. © 2014 IEEE.
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.subjectFlagellar protein
dc.subjectInformation Loss
dc.subjectKullback Leibler divergence
dc.subjectMulti-Kernel Learning
dc.subjectTrypanosma brucei
dc.titleMinimum Information Loss Based Multi-kernel Learning for Flagellar Protein Recognition in Trypanosoma Brucei
dc.typeConference Paper
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentComputer Science Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journal2014 IEEE International Conference on Data Mining Workshop
dc.conference.date14 December 2014
dc.conference.name14th IEEE International Conference on Data Mining Workshops, ICDMW 2014
kaust.personWang, Jim Jing-Yan
kaust.personGao, Xin


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