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    Analysis of different coating thickness on new type of planar interdigital sensors for endotoxin detection

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    Type
    Conference Paper
    Authors
    Syaifudin, A. R Mohd
    Yu, Paklam
    Mukhopadhyay, Subhas Chandra
    Gooneratne, Chinthaka Pasan
    Kosel, Jürgen cc
    KAUST Department
    Sensing, Magnetism and Microsystems Lab
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Date
    2013-05
    Permanent link to this record
    http://hdl.handle.net/10754/564714
    
    Metadata
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    Abstract
    New types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.
    Publisher
    Institute of Electrical & Electronics Engineers (IEEE)
    Journal
    2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)
    Conference/Event name
    2013 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Life, I2MTC 2013
    ISBN
    9781467346221
    ISSN
    10915281
    DOI
    10.1109/I2MTC.2013.6555663
    ae974a485f413a2113503eed53cd6c53
    10.1109/I2MTC.2013.6555663
    Scopus Count
    Collections
    Conference Papers; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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