Analysis of different coating thickness on new type of planar interdigital sensors for endotoxin detection
Type
Conference PaperAuthors
Syaifudin, A. R MohdYu, Paklam
Mukhopadhyay, Subhas Chandra
Gooneratne, Chinthaka Pasan
Kosel, Jürgen

KAUST Department
Sensing, Magnetism and Microsystems LabComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Date
2013-05Permanent link to this record
http://hdl.handle.net/10754/564714
Metadata
Show full item recordAbstract
New types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.Conference/Event name
2013 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Life, I2MTC 2013ISBN
9781467346221ISSN
10915281ae974a485f413a2113503eed53cd6c53
10.1109/I2MTC.2013.6555663