Show simple item record

dc.contributor.authorTheofilatos, Konstantinos A.
dc.contributor.authorDimitrakopoulos, Christos M.
dc.contributor.authorKleftogiannis, Dimitrios A.
dc.contributor.authorMoschopoulos, Charalampos N.
dc.contributor.authorPapadimitriou, Stergios
dc.contributor.authorLikothanassis, Spiridon D.
dc.contributor.authorMavroudi, Seferina P.
dc.date.accessioned2015-08-04T07:02:41Z
dc.date.available2015-08-04T07:02:41Z
dc.date.issued2012
dc.identifier.citationTheofilatos, K., Dimitrakopoulos, C., Kleftogiannis, D., Moschopoulos, C., Papadimitriou, S., Likothanassis, S., & Mavroudi, S. (2012). HINT-KB: The Human Interactome Knowledge Base. Artificial Intelligence Applications and Innovations, 612–621. doi:10.1007/978-3-642-33412-2_63
dc.identifier.isbn9783642334115
dc.identifier.issn18684238
dc.identifier.doi10.1007/978-3-642-33412-2_63
dc.identifier.urihttp://hdl.handle.net/10754/564504
dc.description.abstractProteins and their interactions are considered to play a significant role in many cellular processes. The identification of Protein-Protein interactions (PPIs) in human is an open research area. Many Databases, which contain information about experimentally and computationally detected human PPIs as well as their corresponding annotation data, have been developed. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://150.140.142.24:84/Default.aspx) which is a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, estimates a set of features of interest and computes a confidence score for every candidate protein interaction using a modern computational hybrid methodology. © 2012 IFIP International Federation for Information Processing.
dc.publisherSpringer Nature
dc.subjectGenetic Algorithms
dc.subjectHuman
dc.subjectKalman Filters
dc.subjectKnowledge Base
dc.subjectPPI scoring methods
dc.subjectProtein-Protein Interactions
dc.titleHINT-KB: The human interactome knowledge base
dc.typeConference Paper
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentComputer Science Program
dc.identifier.journalIFIP Advances in Information and Communication Technology
dc.conference.date27 September 2012 through 30 September 2012
dc.conference.name8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB
dc.conference.locationHalkidiki
dc.contributor.institutionDepartment of Computer Engineering and Informatics, University of Patras, Greece
dc.contributor.institutionDepartment of Electrical Engineering-ESAT, SCD-SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, box 2446, 300, Leuven, Belgium
dc.contributor.institutionIBBT Future Health Department, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, box 2446, 300, Leuven, Belgium
dc.contributor.institutionDepartment of Information Management, Technological Institute of Kavala, Greece
dc.contributor.institutionDepartment of Social Work, School of Sciences of Health and Care, Technological Educational Institute of Patras, Greece
kaust.personKleftogiannis, Dimitrios A.


This item appears in the following Collection(s)

Show simple item record