Plant natriuretic peptides: Systemic regulators of plant homeostasis and defense that can affect cardiomyoblasts
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Environmental Science and Engineering Program
Molecular Signalling Group
Online Publication Date2015-12-14
Print Publication Date2013-06-01
Permanent link to this recordhttp://hdl.handle.net/10754/564309
MetadataShow full item record
AbstractImmunologic evidence has suggested the presence of biologically active natriuretic peptide (NPs) hormones in plants because antiatrial NP antibodies affinity purify biologically active plant NPs (PNP). In the model plant, an Arabidopsis thaliana PNP (AtPNP-A) has been identified and characterized. AtPNP-A belongs to a novel class of molecules that share some similarity with the cell wall loosening expansins but do not contain the carbohydrate-binding wall anchor thus suggesting that PNPs and atrial natriuretic peptides are heterologs. AtPNP-A acts systemically, and this is consistent with its localization in the apoplastic extracellular space and the conductive tissue. Furthermore, AtPNP-A signals via the second messenger cyclic guanosine 3′,5′-monophosphate and modulates ion and water transport and homeostasis. It also plays a critical role in host defense against pathogens. AtPNP-A can be classified as novel paracrine plant hormone because it is secreted into the apoplastic space in response to stress and can enhance its own expression. Interestingly, purified recombinant PNP induces apo-ptosis in a dose-dependent manner and was most effective on cardiac myoblast cell lines. Because PNP is mimicking the effect of ANP in some instances, PNP may prove to provide useful leads for development of novel therapeutic NPs. Copyright © 2013 by The American Federation for Medical Research.
CitationGehring, C., & Irving, H. (2013). Plant Natriuretic Peptides. Journal of Investigative Medicine, 61(5), 823–826. doi:10.2310/jim.0b013e3182923395
SponsorsSupported, in part, by a grant from the National Center for Research Resources (R13 RR023236).
- Plant natriuretic peptides are apoplastic and paracrine stress response molecules.
- Authors: Wang YH, Gehring C, Irving HR
- Issue date: 2011 May
- The plant natriuretic peptide receptor is a guanylyl cyclase and enables cGMP-dependent signaling.
- Authors: Turek I, Gehring C
- Issue date: 2016 Jun
- Natriuretic peptides--a class of heterologous molecules in plants.
- Authors: Gehring CA, Irving HR
- Issue date: 2003 Sep
- A natriuretic peptide from Arabidopsis thaliana (AtPNP-A) can modulate catalase 2 activity.
- Authors: Turek I, Wheeler J, Bartels S, Szczurek J, Wang YH, Taylor P, Gehring C, Irving H
- Issue date: 2020 Nov 12
- Induction of apoptosis by plant natriuretic peptides in rat cardiomyoblasts.
- Authors: Wang YH, Ahmar H, Irving HR
- Issue date: 2010 Jun