Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release
Type
ArticleKAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2015-04-27Online Publication Date
2015-04-27Print Publication Date
2015-06-01Permanent link to this record
http://hdl.handle.net/10754/564148
Metadata
Show full item recordAbstract
Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Citation
Li, S., Moosa, B. A., Croissant, J. G., & Khashab, N. M. (2015). Electrostatic Assembly/Disassembly of Nanoscaled Colloidosomes for Light-Triggered Cargo Release. Angewandte Chemie International Edition, 54(23), 6804–6808. doi:10.1002/anie.201501615Sponsors
We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST).Publisher
WileyJournal
Angewandte Chemieae974a485f413a2113503eed53cd6c53
10.1002/anie.201501615