Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Online Publication Date2015-04-27
Print Publication Date2015-06-01
Permanent link to this recordhttp://hdl.handle.net/10754/564148
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AbstractColloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CitationLi, S., Moosa, B. A., Croissant, J. G., & Khashab, N. M. (2015). Electrostatic Assembly/Disassembly of Nanoscaled Colloidosomes for Light-Triggered Cargo Release. Angewandte Chemie International Edition, 54(23), 6804–6808. doi:10.1002/anie.201501615
SponsorsWe gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST).