Enzyme-inspired functional surfactant for aerobic oxidation of activated alcohols to aldehydes in water
KAUST DepartmentImaging and Characterization Core Lab
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
Advanced Nanofabrication, Imaging and Characterization Core Lab
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AbstractWe describe an enzyme-inspired catalytic system based on a rationally designed multifunctional amphiphile. The resulting micelles feature metal-binding sites and stable free radical moieties as well as fluorous pockets that attract and preconcentrate molecular oxygen. In the presence of copper ions, the micelles effect chemoselective aerobic alcohol oxidation under ambient conditions in water, a transformation that is challenging to achieve nonenzymatically.
SponsorsThe authors are grateful to Dr. Virginia Unkefer and Ms. Sarah Almahdali for their help in preparing the manuscript, and to Prof. Mathias Christmann for a helpful discussion. This research was supported by King Abdullah University of Science and Technology.
PublisherAmerican Chemical Society (ACS)