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dc.contributor.authorLi, Song
dc.contributor.authorMoosa, Basem
dc.contributor.authorChen, Ye
dc.contributor.authorLi, Wengang
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-08-03T12:21:14Z
dc.date.available2015-08-03T12:21:14Z
dc.date.issued2015
dc.identifier.issn20507518
dc.identifier.doi10.1039/c4tb01495b
dc.identifier.urihttp://hdl.handle.net/10754/563967
dc.description.abstractFunctional polymeric membranes are widely used to adjust and control the diffusion of molecules. Herein, photosensitive poly(hydroxycinnamic acid) (PHCA) microspheres, which were fabricated by an emulsification solvent-evaporation method, were embedded into an ethyl cellulose matrix to fabricate composite membranes with a photo-tunable property. The photoreaction of PHCA is based on the [2 + 2] cycloaddition of cinnamic moieties upon irradiation with 365 nm light. Intra-particle crosslinking in PHCA microspheres was confirmed in the solution phase, while inter-particle crosslinking between adjacent PHCA microspheres dominated the solid membrane phase. The inter-particle crosslinking turned down the permeability of the composite membranes by 74%. To prove the applicability of the designed system, the composite membrane was coated on a model drug reservoir tablet. Upon irradiating the tablet with UV light, the original permeability decreased by 57%, and consequently the diffusion rate of the cargo (Rhodamine B) from the tablet slowed down. Most importantly, the tablet showed sustained release for over 10 days. This controllability can be further tuned by adjusting the membrane thickness. Composite membranes showed excellent processing reproducibility together with consistent mechanical properties. These results demonstrate that the incorporation of photosensitive PHCA microspheres in polymeric membranes provides a promising photo-tunable material for different applications including coating and separation. This journal is © The Royal Society of Chemistry 2015.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleA photo-tunable membrane based on inter-particle crosslinking for decreasing diffusion rates
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentNumerical Porous Media SRI Center (NumPor)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalJ. Mater. Chem. B
kaust.personLi, Song
kaust.personMoosa, Basem
kaust.personChen, Ye
kaust.personLi, Wengang
kaust.personKhashab, Niveen M.


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