Nonlinear neural network for hemodynamic model state and input estimation using fMRI data
KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Applied Mathematics and Computational Science Program
MetadataShow full item record
AbstractOriginally inspired by biological neural networks, artificial neural networks (ANNs) are powerful mathematical tools that can solve complex nonlinear problems such as filtering, classification, prediction and more. This paper demonstrates the first successful implementation of ANN, specifically nonlinear autoregressive with exogenous input (NARX) networks, to estimate the hemodynamic states and neural activity from simulated and measured real blood oxygenation level dependent (BOLD) signals. Blocked and event-related BOLD data are used to test the algorithm on real experiments. The proposed method is accurate and robust even in the presence of signal noise and it does not depend on sampling interval. Moreover, the structure of the NARX networks is optimized to yield the best estimate with minimal network architecture. The results of the estimated neural activity are also discussed in terms of their potential use.
SponsorsResearch reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). The authors would like to thank anonymous reviewers for valuables comments on the manuscript.