Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
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AbstractDendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
SponsorsThis work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.