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    An efficient biosensor made of an electromagnetic trap and a magneto-resistive sensor

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    Type
    Article
    Authors
    Li, Fuquan cc
    Kosel, Jürgen cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Sensing, Magnetism and Microsystems Lab
    Date
    2014-09
    Permanent link to this record
    http://hdl.handle.net/10754/563722
    
    Metadata
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    Abstract
    Magneto-resistive biosensors have been found to be useful because of their high sensitivity, low cost, small size, and direct electrical output. They use super-paramagnetic beads to label a biological target and detect it via sensing the stray field. In this paper, we report a new setup for magnetic biosensors, replacing the conventional "sandwich" concept with an electromagnetic trap. We demonstrate the capability of the biosensor in the detection of E. coli. The trap is formed by a current-carrying microwire that attracts the magnetic beads into a sensing space on top of a tunnel magneto-resistive sensor. The sensor signal depends on the number of beads in the sensing space, which depends on the size of the beads. This enables the detection of biological targets, because such targets increase the volume of the beads. Experiments were carried out with a 6. μm wide microwire, which attracted the magnetic beads from a distance of 60. μm, when a current of 30. mA was applied. A sensing space of 30. μm in length and 6. μm in width was defined by the magnetic sensor. The results showed that individual E. coli bacterium inside the sensing space could be detected using super-paramagnetic beads that are 2.8. μm in diameter. The electromagnetic trap setup greatly simplifies the device and reduces the detection process to two steps: (i) mixing the bacteria with magnetic beads and (ii) applying the sample solution to the sensor for measurement, which can be accomplished within about 30. min with a sample volume in the μl range. This setup also ensures that the biosensor can be cleaned easily and re-used immediately. The presented setup is readily integrated on chips via standard microfabrication techniques. © 2014 Elsevier B.V.
    Citation
    Li, F., & Kosel, J. (2014). An efficient biosensor made of an electromagnetic trap and a magneto-resistive sensor. Biosensors and Bioelectronics, 59, 145–150. doi:10.1016/j.bios.2014.03.035
    Publisher
    Elsevier BV
    Journal
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2014.03.035
    PubMed ID
    24727202
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bios.2014.03.035
    Scopus Count
    Collections
    Articles; Electrical and Computer Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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