Demography-adjusted tests of neutrality based on genome-wide SNP data
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Integrative Systems Biology Lab
Permanent link to this recordhttp://hdl.handle.net/10754/563677
MetadataShow full item record
AbstractTests of the neutral evolution hypothesis are usually built on the standard model which assumes that mutations are neutral and the population size remains constant over time. However, it is unclear how such tests are affected if the last assumption is dropped. Here, we extend the unifying framework for tests based on the site frequency spectrum, introduced by Achaz and Ferretti, to populations of varying size. Key ingredients are the first two moments of the site frequency spectrum. We show how these moments can be computed analytically if a population has experienced two instantaneous size changes in the past. We apply our method to data from ten human populations gathered in the 1000 genomes project, estimate their demographies and define demography-adjusted versions of Tajima's D, Fay & Wu's H, and Zeng's E. Our results show that demography-adjusted test statistics facilitate the direct comparison between populations and that most of the differences among populations seen in the original unadjusted tests can be explained by their underlying demographies. Upon carrying out whole-genome screens for deviations from neutrality, we identify candidate regions of recent positive selection. We provide track files with values of the adjusted and unadjusted tests for upload to the UCSC genome browser. © 2014 Elsevier Inc.
CitationRafajlović, M., Klassmann, A., Eriksson, A., Wiehe, T., & Mehlig, B. (2014). Demography-adjusted tests of neutrality based on genome-wide SNP data. Theoretical Population Biology, 95, 1–12. doi:10.1016/j.tpb.2014.05.002
SponsorsThis work was financially supported by grants from Vetenskapsradet, from the Goran Gustafsson Foundation for Research in Natural Sciences and Medicine, through the Linnaeus Centre for Marine Evolutionary Biology (CeMEB, www.cemeb.science.gu.se) to BM, by a grant of the German Science Foundation (DFG-SFB680) to TW, and AE by the Leverhume Trust and the Biotechnology and Biological Sciences Research Council (Grant BB/H005854/1).
JournalTheoretical Population Biology
- A new test for detecting recent positive selection that is free from the confounding impacts of demography.
- Authors: Li H
- Issue date: 2011 Jan
- Optimal neutrality tests based on the frequency spectrum.
- Authors: Ferretti L, Perez-Enciso M, Ramos-Onsins S
- Issue date: 2010 Sep
- Postglacial history of a widespread conifer produces inverse clines in selective neutrality tests.
- Authors: Holliday JA, Yuen M, Ritland K, Aitken SN
- Issue date: 2010 Sep
- Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests.
- Authors: Ferretti L, Ledda A, Wiehe T, Achaz G, Ramos-Onsins SE
- Issue date: 2017 Sep
- Detecting directional selection in the presence of recent admixture in African-Americans.
- Authors: Lohmueller KE, Bustamante CD, Clark AG
- Issue date: 2011 Mar