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    Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

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    Type
    Article
    Authors
    Yu, Haizhou
    Qiu, Xiaoyan
    Nunes, Suzana Pereira cc
    Peinemann, Klaus-Viktor cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Water Desalination and Reuse Research Center (WDRC)
    Biological and Environmental Sciences and Engineering (BESE) Division
    Environmental Science and Engineering Program
    Physical Sciences and Engineering (PSE) Division
    Chemical and Biological Engineering Program
    Nanostructured Polymeric Membrane Lab
    Date
    2014-06-17
    Permanent link to this record
    http://hdl.handle.net/10754/563600
    
    Metadata
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    Abstract
    The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances. © 2014 Macmillan Publishers Limited.
    Sponsors
    The authors gratefully acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), and also thank Dr Ali Reza Behzad and Dr Lan Zhao from the Advanced Nanofabrication, Imaging and Characterization Lab at KAUST for help with the Cryo-FESEM and SEM.
    Publisher
    Nature Publishing Group
    Journal
    Nature Communications
    ISSN
    20411723
    DOI
    10.1038/ncomms5110
    PubMed ID
    24934665
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncomms5110
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Physical Sciences and Engineering (PSE) Division; Chemical and Biological Engineering Program; Water Desalination and Reuse Research Center (WDRC)

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