• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Type
    Article
    Authors
    Yu, Haizhou
    Qiu, Xiaoyan
    Nunes, Suzana Pereira cc
    Peinemann, Klaus-Viktor cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Biological and Environmental Sciences and Engineering (BESE) Division
    Chemical Engineering Program
    Environmental Science and Engineering Program
    Nanostructured Polymeric Membrane Lab
    Physical Science and Engineering (PSE) Division
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2014-06-17
    Online Publication Date
    2014-06-17
    Print Publication Date
    2014-12
    Permanent link to this record
    http://hdl.handle.net/10754/563600
    
    Metadata
    Show full item record
    Abstract
    The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances. © 2014 Macmillan Publishers Limited.
    Citation
    Yu, H., Qiu, X., Nunes, S. P., & Peinemann, K.-V. (2014). Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity. Nature Communications, 5(1). doi:10.1038/ncomms5110
    Sponsors
    The authors gratefully acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), and also thank Dr Ali Reza Behzad and Dr Lan Zhao from the Advanced Nanofabrication, Imaging and Characterization Lab at KAUST for help with the Cryo-FESEM and SEM.
    Publisher
    Springer Nature
    Journal
    Nature Communications
    DOI
    10.1038/ncomms5110
    PubMed ID
    24934665
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncomms5110
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Physical Science and Engineering (PSE) Division; Chemical Engineering Program; Water Desalination and Reuse Research Center (WDRC)

    entitlement

    Related articles

    • Thermo- and pH-sensitive ionic-crosslinked hollow spheres from chitosan-based graft copolymer for 5-fluorouracil release.
    • Authors: Li G, Guo L, Wen Q, Zhang T
    • Issue date: 2013 Apr
    • Synthesis of mesoporous hollow silica nanospheres using polymeric micelles as template and their application as a drug-delivery carrier.
    • Authors: Sasidharan M, Zenibana H, Nandi M, Bhaumik A, Nakashima K
    • Issue date: 2013 Oct 7
    • Synthesis of amphiphilic superparamagnetic ferrite/block copolymer hollow submicrospheres.
    • Authors: Li XH, Zhang DH, Chen JS
    • Issue date: 2006 Jul 5
    • Porous microspheres of amorphous calcium phosphate: block copolymer templated microwave-assisted hydrothermal synthesis and application in drug delivery.
    • Authors: Ding GJ, Zhu YJ, Qi C, Lu BQ, Wu J, Chen F
    • Issue date: 2015 Apr 1
    • Ultrasmall, well-dispersed, hollow siliceous spheres with enhanced endocytosis properties.
    • Authors: Zhu J, Tang J, Zhao L, Zhou X, Wang Y, Yu C
    • Issue date: 2010 Jan
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.