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    Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

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    Type
    Article
    Authors
    Liu, Qingxin
    Wang, Xianfeng
    Ikeo, Kazuho
    Hirose, Susumu
    Gehring, Walter Jakob
    Gojobori, Takashi cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Computational Bioscience Research Center (CBRC)
    Environmental Science and Engineering Program
    Bioscience Program
    Date
    2014-06-16
    Online Publication Date
    2014-06-16
    Print Publication Date
    2014-07-01
    Permanent link to this record
    http://hdl.handle.net/10754/563598
    
    Metadata
    Show full item record
    Abstract
    During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.
    Citation
    Liu, Q.-X., Wang, X.-F., Ikeo, K., Hirose, S., Gehring, W. J., & Gojobori, T. (2014). Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducingcyclin Eduring eye development. Proceedings of the National Academy of Sciences, 111(26), 9497–9502. doi:10.1073/pnas.1407145111
    Sponsors
    We thank Helena Richardson for Cyclin E antibody and Yash Hiromi for valuable suggestions. This work was supported by National Basic Research Program of China Grant 2012CB114600 (to Q.-X. L. and X.-F.W.), a Grant in Aid for Scientific Research (to S. H.), and a Research Grant for the Cell Innovation Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to K.I. and T.G.).
    Publisher
    Proceedings of the National Academy of Sciences
    Journal
    Proceedings of the National Academy of Sciences
    DOI
    10.1073/pnas.1407145111
    PubMed ID
    24979795
    PubMed Central ID
    PMC4084451
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084451
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1407145111
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Environmental Science and Engineering Program; Computational Bioscience Research Center (CBRC)

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