Show simple item record

dc.contributor.authorBourantas, George C.
dc.contributor.authorGhommem, Mehdi
dc.contributor.authorKagadis, George C.
dc.contributor.authorKatsanos, Konstantinos H.
dc.contributor.authorLoukopoulos, Vassilios C.
dc.contributor.authorBurganos, Vasilis N.
dc.contributor.authorNikiforidis, George C.
dc.date.accessioned2015-08-03T11:53:51Z
dc.date.available2015-08-03T11:53:51Z
dc.date.issued2014-04-21
dc.identifier.issn00942405
dc.identifier.pmid24784405
dc.identifier.doi10.1118/1.4870976
dc.identifier.urihttp://hdl.handle.net/10754/563534
dc.description.abstractPurpose: The dynamic mode decomposition (DMD) method is used to provide a reliable forecasting of tumor ablation treatment simulation in real time, which is quite needed in medical practice. To achieve this, an extended Pennes bioheat model must be employed, taking into account both the water evaporation phenomenon and the tissue damage during tumor ablation. Methods: A meshless point collocation solver is used for the numerical solution of the governing equations. The results obtained are used by the DMD method for forecasting the numerical solution faster than the meshless solver. The procedure is first validated against analytical and numerical predictions for simple problems. The DMD method is then applied to three-dimensional simulations that involve modeling of tumor ablation and account for metabolic heat generation, blood perfusion, and heat ablation using realistic values for the various parameters. Results: The present method offers very fast numerical solution to bioheat transfer, which is of clinical significance in medical practice. It also sidesteps the mathematical treatment of boundaries between tumor and healthy tissue, which is usually a tedious procedure with some inevitable degree of approximation. The DMD method provides excellent predictions of the temperature profile in tumors and in the healthy parts of the tissue, for linear and nonlinear thermal properties of the tissue. Conclusions: The low computational cost renders the use of DMD suitable forin situ real time tumor ablation simulations without sacrificing accuracy. In such a way, the tumor ablation treatment planning is feasible using just a personal computer thanks to the simplicity of the numerical procedure used. The geometrical data can be provided directly by medical image modalities used in everyday practice. © 2014 American Association of Physicists in Medicine.
dc.publisherWiley
dc.subjectbioheat equation
dc.subjectEulerian
dc.subjectmeshless method
dc.subjectmoving least squares
dc.subjectthermal ablation
dc.titleReal-time tumor ablation simulation based on the dynamic mode decomposition method
dc.typeArticle
dc.contributor.departmentNumerical Porous Media SRI Center (NumPor)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalMedical Physics
dc.contributor.institutionMax Planck Inst Mol Cell Biol & Genet, MOSAIC Grp, D-01307 Dresden, Germany
dc.contributor.institutionUniv Patras, Sch Med, Dept Med Phys, GR-26504 Rion, Greece
dc.contributor.institutionUniv Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA
dc.contributor.institutionSt Thomas Hosp, Kings Coll London, Div Endovascular Spine & Intervent Oncol, London SE1 7EH, England
dc.contributor.institutionUniv Patras, Dept Phys, Rion 26500, Greece
dc.contributor.institutionFdn Res & Technol, Inst Chem Engn Sci, Patras 26504, Greece
kaust.personGhommem, Mehdi
dc.date.published-online2014-04-21
dc.date.published-print2014-04-21


This item appears in the following Collection(s)

Show simple item record