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    The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation

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    Type
    Article
    Authors
    Naganuma, Tamaki
    Traversa, Enrico cc
    KAUST Department
    KAUST Solar Center (KSC)
    Material Science and Engineering Program
    Materials for Energy Conversion and Storage (MECS) Lab
    Physical Science and Engineering (PSE) Division
    Date
    2014-05
    Permanent link to this record
    http://hdl.handle.net/10754/563533
    
    Metadata
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    Abstract
    Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lactide (PL) scaffold surfaces were functionalized using layers of cerium oxide nanoparticles (CNPs), which have recently attracted attention for use in therapeutic application due to their catalytic ability of Ce4+ and Ce3+ sites. To isolate the influence of Ce valance states of CNPs on cell proliferation, human mesenchymal stem cells (hMSCs) and osteoblast-like cells (MG63) were cultured on the PL/CNP surfaces with dominant Ce4+ and Ce3+ regions. Despite cell type (hMSCs and MG63 cells), different surface features of Ce4+ and Ce3+ regions clearly promoted and inhibited cell spreading, migration and adhesion behavior, resulting in rapid and slow cell proliferation, respectively. Cell proliferation results of various modified CNPs with different surface charge and hydrophobicity/hydrophilicity, indicate that Ce valence states closely correlated with the specific cell morphologies and cell-material interactions that trigger cell proliferation. This finding suggests that the cell-material interactions, which influence cell proliferation, may be controlled by introduction of metal elements with different valence states onto the biomaterial surface. © 2014 Elsevier Ltd.
    Citation
    Naganuma, T., & Traversa, E. (2014). The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation. Biomaterials, 35(15), 4441–4453. doi:10.1016/j.biomaterials.2014.01.074
    Sponsors
    This work was supported, in part, by the World Premier International (WPI) Research Center Initiative Program. Technical support by the Bio-Organic Materials Facility in the Nanotechnology Innovation Station, NIMS, Japan is acknowledged. The authors thank Ms. H. Morita and Dr. X. LI for technical support and suggestions about biological experiments, Ms. S. Kajiwara for technical support of confocal microscope observations (Nanotechnology Innovation Station, NIMS, Japan). We would like to thank Prof. T. Aoyagi (International Center for Materials Nanoarchitectonics, NIMS, Japan) and Dr. L Ghibelli (University of Rome Tor Vergata) for invaluable discussions.
    Publisher
    Elsevier BV
    Journal
    Biomaterials
    DOI
    10.1016/j.biomaterials.2014.01.074
    PubMed ID
    24612920
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.biomaterials.2014.01.074
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program; KAUST Solar Center (KSC)

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