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dc.contributor.authorWatanabe, Junichi
dc.contributor.authorHattori, Masahira
dc.contributor.authorBerriman, Matthew
dc.contributor.authorLehane, Michael J.
dc.contributor.authorHall, Neil
dc.contributor.authorSolano, Philippe
dc.contributor.authorAksoy, Serap
dc.contributor.authorHide, Winston
dc.contributor.authorTouré, Yéya Tiémoko
dc.contributor.authorAttardo, Geoffrey M.
dc.contributor.authorDarby, Alistair Charles
dc.contributor.authorToyoda, Atsushi
dc.contributor.authorHertz-Fowler, Christiane
dc.contributor.authorLarkin, Denis M.
dc.contributor.authorCotton, James A.
dc.contributor.authorSanders, Mandy J.
dc.contributor.authorSwain, Martin T.
dc.contributor.authorQuail, Michael A.
dc.contributor.authorInoue, Noboru
dc.contributor.authorRavel, Sophie
dc.contributor.authorTaylor, Todd Duane
dc.contributor.authorSrivastava, Tulika P.
dc.contributor.authorSharma, Vineet Kumar
dc.contributor.authorWarren, Wesley C.
dc.contributor.authorWilson, Richard K.
dc.contributor.authorSuzuki, Yutaka
dc.contributor.authorLawson, Daniel
dc.contributor.authorHughes, Daniel Seth Toney
dc.contributor.authorMegy, Karyn
dc.contributor.authorMasiga, Daniel K.
dc.contributor.authorMireji, Paul Odhiambo
dc.contributor.authorHansen, Immo Alex
dc.contributor.authorVan Den Abbeele, Jan
dc.contributor.authorBenoit, Joshua B.
dc.contributor.authorBourtzis, Kostas
dc.contributor.authorObiero, George F O
dc.contributor.authorRobertson, Hugh M.
dc.contributor.authorJones, Jeffery W.
dc.contributor.authorZhou, Jingjiang
dc.contributor.authorField, Linda M.
dc.contributor.authorFriedrich, Markus
dc.contributor.authorNyanjom, Steven R G
dc.contributor.authorTelleria, Erich Loza
dc.contributor.authorCaljon, Guy
dc.contributor.authorRibeiro, José M. C.
dc.contributor.authorAcosta-Serrano, Alvaro
dc.contributor.authorOoi, Cherpheng
dc.contributor.authorRose, Clair
dc.contributor.authorPrice, David P.
dc.contributor.authorHaines, Lee Rafuse
dc.contributor.authorChristoffels, Alan G.
dc.contributor.authorSim, Cheolho
dc.contributor.authorPham, Daphne Q D
dc.contributor.authorDenlinger, David L.
dc.contributor.authorGeiser, Dawn L.
dc.contributor.authorOmedo, Irene A.
dc.contributor.authorWinzerling, Joy J.
dc.contributor.authorPeyton, Justin T.
dc.contributor.authorMarucha, Kevin K.
dc.contributor.authorJonas, Mario
dc.contributor.authorMeuti, Megan E.
dc.contributor.authorRawlings, Neil David
dc.contributor.authorZhang, Qirui
dc.contributor.authorMacharia, Rosaline Wanjiru
dc.contributor.authorMichalkova, Veronika
dc.contributor.authorDashti, Zahra Jalali Sefid
dc.contributor.authorBaumann, Aaron A.
dc.contributor.authorGäde, Gerd
dc.contributor.authorMarco, Heather G.
dc.contributor.authorCaers, Jelle
dc.contributor.authorSchoofs, Liliane
dc.contributor.authorRiehle, Michael A.
dc.contributor.authorHu, Wanqi
dc.contributor.authorTu, Zhijian
dc.contributor.authorTarone, Aaron M.
dc.contributor.authorMalacrida, Anna Rodolfa
dc.contributor.authorKibet, Caleb K.
dc.contributor.authorScolari, Francesca
dc.contributor.authorKoekemoer, J. J. O.
dc.contributor.authorWillis, Judith H.
dc.contributor.authorGomulski, Ludvik M.
dc.contributor.authorFalchetto, Marco
dc.contributor.authorScott, Maxwell J.
dc.contributor.authorFu, Shuhua
dc.contributor.authorSze, Singhoi
dc.contributor.authorLuiz, Thiago
dc.contributor.authorWeiss, Brian L.
dc.contributor.authorWalshe, Deirdre P.
dc.contributor.authorWang, Jingwen
dc.contributor.authorWamalwa, Mark
dc.contributor.authorMwangi, Sarah
dc.contributor.authorRamphul, Urvashi N.
dc.contributor.authorSnyder, Anna K.
dc.contributor.authorBrelsfoard, Corey L.
dc.contributor.authorThomas, Gavin H.
dc.contributor.authorTsiamis, George
dc.contributor.authorArensburger, Peter
dc.contributor.authorRio, Rita V M
dc.contributor.authorMacdonald, Sandy J.
dc.contributor.authorPanji, Sumir
dc.contributor.authorKruger, Adele F.
dc.contributor.authorBenkahla, Alia
dc.contributor.authorBalyeidhusa, Apollo Simon Peter
dc.contributor.authorMsangi, Atway R.
dc.contributor.authorOkoro, Chinyere K.
dc.contributor.authorStephens, Dawn
dc.contributor.authorStanley, Eleanor J.
dc.contributor.authorMpondo, Feziwe
dc.contributor.authorWamwiri, Florence N.
dc.contributor.authorMramba, Furaha
dc.contributor.authorSiwo, Geoffrey H.
dc.contributor.authorGithinji, George
dc.contributor.authorHarkins, Gordon William
dc.contributor.authorMurilla, Grace Adira
dc.contributor.authorLehväslaiho, Heikki
dc.contributor.authorMalele, Imna I.
dc.contributor.authorAuma, Joanna Eseri
dc.contributor.authorKinyua, Johnson K.
dc.contributor.authorOuma, Johnson O.
dc.contributor.authorOkedi, Loyce M A
dc.contributor.authorManga, Lucien
dc.contributor.authorAslett, Martin A.
dc.contributor.authorKoffi, Mathurin
dc.contributor.authorGaunt, Michael W.
dc.contributor.authorMakgamathe, Mmule
dc.contributor.authorMulder, Nicola Jane
dc.contributor.authorManangwa, Oliver
dc.contributor.authorAbila, Patrick P.
dc.contributor.authorWincker, Patrick
dc.contributor.authorGregory, Richard I.
dc.contributor.authorBateta, Rosemary
dc.contributor.authorSakate, Ryuichi
dc.contributor.authorOmmeh, Sheila
dc.contributor.authorLehane, Stella M.
dc.contributor.authorImanishi, Tadashi
dc.contributor.authorOsamor, Victor Chukwudi
dc.contributor.authorKawahara, Yoshihiro
dc.date.accessioned2015-08-03T11:53:15Z
dc.date.available2015-08-03T11:53:15Z
dc.date.issued2014-04-24
dc.identifier.issn00368075
dc.identifier.pmid24763584
dc.identifier.doi10.1126/science.1249656
dc.identifier.urihttp://hdl.handle.net/10754/563509
dc.description.abstractTsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
dc.description.sponsorshipThe public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts," the European Union Cooperation in Science and Technology (COST) Action FA0701 "Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management," and a grant-in-aid for Scientific Research on Priority Areas "Comprehensive Genomics" from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077534
dc.relation.urlhttp://europepmc.org/articles/pmc4077534?pdf=render
dc.rightsArchived with thanks to American Association for the Advancement of Science (AAAS)
dc.rightsThis file is an open access version redistributed from: http://europepmc.org/articles/pmc4077534?pdf=render
dc.titleGenome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalScience
dc.identifier.pmcidPMC4077534
dc.eprint.versionPost-print
dc.contributor.institutionBiological Sciences Department, California State Polytechnic University Pomona, 3801 West Temple Avenue, Pomona, CA 91768, United States
dc.contributor.institutionBiomedical Sciences Research Center, Alexander Fleming Biomedical Sciences Research Center, 34 Fleming Street, Vari, 16672, Greece
dc.contributor.institutionCEA, Genoscope, 2 Rue Gaston Crémieux, Evry Cedex, 91507, France
dc.contributor.institutionCenter for Biotechnology and Bioinformatics, University of Nairobi, Post Office Box 30197-00100, Nairobi, Kenya
dc.contributor.institutionCenter for Omics and Bioinformatics, Department of Computational Biology, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan
dc.contributor.institutionComparative Genomics Laboratory, National Institute of Genetics, 411-8540 Yata 1111, Mishima, Shizuoka, 411-8540, Japan
dc.contributor.institutionComputational Biology Group, IIDMM, University of Cape Town Faculty of Health Sciences, Cape Town, 7925, South Africa
dc.contributor.institutionDepartment of Biochemistry and Biophysics, Texas A and M University, 328B TAMU, College Station, TX 77843, United States
dc.contributor.institutionDepartment of Biochemistry and Molecular Biology, Egerton University, Post Office Box 536, Njoro, Kenya
dc.contributor.institutionDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Post Office Box 62000-00200, Nairobi, Kenya
dc.contributor.institutionDepartment of Biochemistry, Virginia Polytechnic Institute and State University, 309 Fralin Hall, Blacksburg, VA 24061, United States
dc.contributor.institutionDepartment of Biological Chemistry and Crop Protection, Rothamsted Research, West Common, Harpenden, Herts, AL5 2JQ, United Kingdom
dc.contributor.institutionDepartment of Biological Sciences, McMicken College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221, United States
dc.contributor.institutionDepartment of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, ZA-7700, South Africa
dc.contributor.institutionDepartment of Biological Sciences, University of Wisconsin-Parkside, 900 Wood Road, Kenosha, WI 53144, United States
dc.contributor.institutionDepartment of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, United States
dc.contributor.institutionDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, Pavia, 27100, Italy
dc.contributor.institutionDepartment of Biology, Baylor University, Waco, TX 76798, United States
dc.contributor.institutionDepartment of Biology, KU Leuven, Naamsestraat 59, Leuven, B-3000, Belgium
dc.contributor.institutionDepartment of Biology, New Mexico State University, Foster Hall 263, Las Cruces, NM 88003, United States
dc.contributor.institutionDepartment of Biology, University of York, Wentworth Way, York, Y010 5DD, United Kingdom
dc.contributor.institutionDepartment of Biology, West Virginia University, 5106 LSB, 53 Campus Drive, Morgantown, WV, United States
dc.contributor.institutionDepartment of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Nationalestraat 155, Antwerp, B-2000, Belgium
dc.contributor.institutionDepartment of Cellular Biology, University of Georgia, 302 Biological Sciences Building, Athens, GA 30602, United States
dc.contributor.institutionDepartment of Clinical Research, KEMRI-Wellcome Trust Programme, CGMRC, Post Office Box 230-80108, Kilifi, Kenya
dc.contributor.institutionDepartment of Computer and Information Sciences, College of Science and Technology, Covenant University, P.M.B. 1023, Ota, Ogun State, Nigeria
dc.contributor.institutionDepartment of Computer Science and Engineering, Texas A and M University, HRBB 328B TAMU, College Station, TX 77843, United States
dc.contributor.institutionDepartment of Entomology, North Carolina State University, Campus Box 7613, Raleigh, NC 27695-7613, United States
dc.contributor.institutionDepartment of Entomology, Texas A and M University, 2475 TAMU, College Station, TX 77843, United States
dc.contributor.institutionDepartment of Entomology, Ohio State University, 400 Aronoff Laboratory, 318 West 12th Avenue, Columbus, OH 43210, United States
dc.contributor.institutionDepartment of Entomology, University of Arizona, Forbes 410, 1140 East South Campus Drive, Tucson, AZ 85721, United States
dc.contributor.institutionDepartment of Entomology, University of Illinois at Urbana-Champaign, 505 South Goodwin Avenue, Urbana, IL 61801, United States
dc.contributor.institutionInsect Pest Control Laboratory, Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, 1220, Austria
dc.contributor.institutionDepartment of Environmental and Natural Resources Management, University of Patras, 2 Seferi Street, Agrinio, 30100, Greece
dc.contributor.institutionDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06520, United States
dc.contributor.institutionDepartment of Evolution, Ecology, and Organismal Biology, Ohio State University, 300 Aronoff Laboratory, 318 West 12th Avenue, Columbus, OH 43210, United States
dc.contributor.institutionDepartment of Natural Sciences, St. Catharine College, 2735 Bardstown Road, St. Catharine, KY 40061, United States
dc.contributor.institutionDepartment of Nutritional Sciences, University of Arizona, College of Agriculture and Life Sciences, Post Office Box 210036, Tucson, AZ 85721-0036, United States
dc.contributor.institutionDepartment of Nutritional Sciences, University of Arizona, Shantz 405, 1177 East 4th Street, Tucson, AZ 85721-0038, United States
dc.contributor.institutionDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
dc.contributor.institutionDepartment of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
dc.contributor.institutionDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
dc.contributor.institutionEntomology Section, Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort, 110, South Africa
dc.contributor.institutionEck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, United States
dc.contributor.institutionDepartment of Veterinary Tropical Diseases, University of Pretoria, Private Bag X04, Onderstepoort, 110, South Africa
dc.contributor.institutionEuropean Molecular Biology Laboratories, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, United Kingdom
dc.contributor.institutionGroup of Bioinformatics and Modeling, Laboratory of Medical Parasitology, Biotechnology, and Biomolecules, Institut Pasteur de Tunis, 13, Place Pasteur, Belvédère, Tunis, 1002, Tunisia
dc.contributor.institutionInstitut de Recherche Pour le Développement (IRD), UMR 177 IRD-CIRAD INTERTRYP, CIRDES Bobo-Dioulasso, Burkina Faso
dc.contributor.institutionInstitut de Recherche Pour le Développement (IRD), UMR 177 IRD-CIRAD INTERTRYP, LRCT Campus International de Baillarguet, Montpellier, France
dc.contributor.institutionInstitute of Biological, Environmental, and Rural Sciences, University of Aberystwyth, Old College, King Street, Aberystwyth, Ceredigion, SY23 3FG, United Kingdom
dc.contributor.institutionInstitute of Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Post Office Box 62000-00200, Nairobi, Kenya
dc.contributor.institutionInstitute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, United Kingdom
dc.contributor.institutionInstitute of Zoology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 06, Slovakia
dc.contributor.institutionIntegrated Database Team, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Aomi 2-4-7, Koto-ku, Tokyo, 135-0064, Japan
dc.contributor.institutionKenya Agricultural Research Institute, Trypanosomiasis Research Centre, Post Office Box 362, Kikuyu, 902, Kenya
dc.contributor.institutionLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Rockville, MD 20852, United States
dc.contributor.institutionTechnology Innovation Agency, National Genomics Platform, Post Office Box 30603, Mayville, Durban, 4058, South Africa
dc.contributor.institutionDepartment of Biochemistry and Sports Science, Makerere University, Post Office Box 7062, Kampala, Uganda
dc.contributor.institutionBateman Group, EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, United Kingdom
dc.contributor.institutionMolecular Biology and Bioinformatics Unit, International Center of Insect Physiology and Ecology, Duduville Campus, Kasarani, Post Office Box 30772-00100, Nairobi, Kenya
dc.contributor.institutionNational Livestock Resources Research Institute (NaLIRRI), Post Office Box 96, Tororo, Uganda
dc.contributor.institutionNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan
dc.contributor.institutionParasite Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, United Kingdom
dc.contributor.institutionRiddiford Laboratory, Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, United States
dc.contributor.institutionRIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumiku, Yokohama, Kanagawa, 230-0045, Japan
dc.contributor.institutionSouth African National Bioinformatics Institute, South African MRC Bioinformatics Unit, University of the Western Cape, Modderdam Road, Bellville 7530, South Africa
dc.contributor.institutionSpecial Programme for Research and Training in Tropical Diseases (TDR), WHO, Avenue Appia 20, 1211 Geneva 27, Switzerland
dc.contributor.institutionGenome Institute, Washington University School of Medicine, St. Louis, MO 63110, United States
dc.contributor.institutionTsetse and Trypanosomiasis Research Institute (TTRI), Majani Mapana, Off Korogwe Road, Tanga, Tanzania
dc.contributor.institutionVector Health International, Post Office Box 15500, Arusha, Tanzania
dc.contributor.institutionWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, United Kingdom
dc.contributor.institutionWHO Regional Office for Africa, WHO, Cité du Djoué, Post Office Box 06, Brazzaville, Congo
dc.contributor.institutionSchool of Basic Sciences, Indian Institute of Technology, Mandi 175001, Himachal Pradesh, India
dc.contributor.institutionDepartment of Parasite, Vector, and Human Biology, KEMRI-Wellcome Trust Programme, CGMRC, Post Office Box 230-80108, Kilifi, Kenya
dc.contributor.institutionInstitute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
dc.contributor.institutionDepartment of Biochemistry and Biotechnology, Kenyatta University, Post Office Box 43844-00100, Nairobi, Kenya
dc.contributor.institutionDepartment of Biological Sciences, Indian Institute of Science Education and Research, Indore Bypass Road, Bhauri District, Bhopal, Madhya Pradesh, 462066, India
dc.contributor.institutionFaculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
dc.contributor.institutionDepartment of Biostatistics, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02461, United States
dc.contributor.institutionBioinformatics Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, 2-1-2, Kannondai, Tsukuba, Ibaraki 305-8602, Japan
kaust.personLehväslaiho, Heikki
refterms.dateFOA2020-07-02T12:31:54Z
dc.date.published-online2014-04-24
dc.date.published-print2014-04-25


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