Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis
Type
ArticleAuthors
Watanabe, JunichiHattori, Masahira
Berriman, Matthew
Lehane, Michael J.
Hall, Neil
Solano, Philippe
Aksoy, Serap
Hide, Winston
Touré, Yéya Tiémoko
Attardo, Geoffrey M.
Darby, Alistair Charles
Toyoda, Atsushi
Hertz-Fowler, Christiane
Larkin, Denis M.
Cotton, James A.
Sanders, Mandy J.
Swain, Martin T.
Quail, Michael A.
Inoue, Noboru
Ravel, Sophie
Taylor, Todd Duane
Srivastava, Tulika P.
Sharma, Vineet Kumar
Warren, Wesley C.
Wilson, Richard K.
Suzuki, Yutaka
Lawson, Daniel
Hughes, Daniel Seth Toney
Megy, Karyn
Masiga, Daniel K.
Mireji, Paul Odhiambo
Hansen, Immo Alex
Van Den Abbeele, Jan
Benoit, Joshua B.
Bourtzis, Kostas
Obiero, George F O
Robertson, Hugh M.
Jones, Jeffery W.
Zhou, Jingjiang
Field, Linda M.
Friedrich, Markus
Nyanjom, Steven R G
Telleria, Erich Loza
Caljon, Guy
Ribeiro, José M. C.
Acosta-Serrano, Alvaro
Ooi, Cherpheng
Rose, Clair
Price, David P.
Haines, Lee Rafuse
Christoffels, Alan G.
Sim, Cheolho
Pham, Daphne Q D
Denlinger, David L.
Geiser, Dawn L.
Omedo, Irene A.
Winzerling, Joy J.
Peyton, Justin T.
Marucha, Kevin K.
Jonas, Mario
Meuti, Megan E.
Rawlings, Neil David
Zhang, Qirui
Macharia, Rosaline Wanjiru
Michalkova, Veronika
Dashti, Zahra Jalali Sefid
Baumann, Aaron A.
Gäde, Gerd
Marco, Heather G.
Caers, Jelle
Schoofs, Liliane
Riehle, Michael A.
Hu, Wanqi
Tu, Zhijian
Tarone, Aaron M.
Malacrida, Anna Rodolfa
Kibet, Caleb K.
Scolari, Francesca
Koekemoer, J. J. O.
Willis, Judith H.
Gomulski, Ludvik M.
Falchetto, Marco
Scott, Maxwell J.
Fu, Shuhua
Sze, Singhoi
Luiz, Thiago
Weiss, Brian L.
Walshe, Deirdre P.
Wang, Jingwen
Wamalwa, Mark
Mwangi, Sarah
Ramphul, Urvashi N.
Snyder, Anna K.
Brelsfoard, Corey L.
Thomas, Gavin H.
Tsiamis, George
Arensburger, Peter
Rio, Rita V M
Macdonald, Sandy J.
Panji, Sumir
Kruger, Adele F.
Benkahla, Alia
Balyeidhusa, Apollo Simon Peter
Msangi, Atway R.
Okoro, Chinyere K.
Stephens, Dawn
Stanley, Eleanor J.
Mpondo, Feziwe
Wamwiri, Florence N.
Mramba, Furaha
Siwo, Geoffrey H.
Githinji, George
Harkins, Gordon William
Murilla, Grace Adira
Lehväslaiho, Heikki
Malele, Imna I.
Auma, Joanna Eseri
Kinyua, Johnson K.
Ouma, Johnson O.
Okedi, Loyce M A
Manga, Lucien
Aslett, Martin A.
Koffi, Mathurin
Gaunt, Michael W.
Makgamathe, Mmule
Mulder, Nicola Jane
Manangwa, Oliver
Abila, Patrick P.
Wincker, Patrick
Gregory, Richard I.
Bateta, Rosemary
Sakate, Ryuichi
Ommeh, Sheila
Lehane, Stella M.
Imanishi, Tadashi
Osamor, Victor Chukwudi
Kawahara, Yoshihiro
Date
2014-04-24Online Publication Date
2014-04-24Print Publication Date
2014-04-25Permanent link to this record
http://hdl.handle.net/10754/563509
Metadata
Show full item recordAbstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.Citation
Attardo, G. M., Abila, P. P., Auma, J. E., Baumann, A. A., Benoit, J. B., Brelsfoard, C. L., Ribeiro, J. M. C., Cotton, J. A., Pham, D. Q. D., Darby, A. C., Van Den Abbeele, J., Denlinger, D. L., Field, L. M., Nyanjom, S. R. G., Gaunt, M. W., Geiser, D. L., Gomulski, L. M., Haines, L. R., … Zhou, J.-J. (2014). Genome Sequence of the Tsetse Fly ( Glossina morsitans ): Vector of African Trypanosomiasis. Science, 344(6182), 380–386. https://doi.org/10.1126/science.1249656Sponsors
The public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts," the European Union Cooperation in Science and Technology (COST) Action FA0701 "Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management," and a grant-in-aid for Scientific Research on Priority Areas "Comprehensive Genomics" from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.Journal
SciencePubMed ID
24763584PubMed Central ID
PMC4077534Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077534http://europepmc.org/articles/pmc4077534?pdf=render
ae974a485f413a2113503eed53cd6c53
10.1126/science.1249656
Scopus Count
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