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    Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

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    Type
    Article
    Authors
    Watanabe, Junichi
    Hattori, Masahira
    Berriman, Matthew
    Lehane, Michael J.
    Hall, Neil
    Solano, Philippe
    Aksoy, Serap
    Hide, Winston
    Touré, Yéya Tiémoko
    Attardo, Geoffrey M.
    Darby, Alistair Charles
    Toyoda, Atsushi
    Hertz-Fowler, Christiane
    Larkin, Denis M.
    Cotton, James A.
    Sanders, Mandy J.
    Swain, Martin T.
    Quail, Michael A.
    Inoue, Noboru
    Ravel, Sophie
    Taylor, Todd Duane
    Srivastava, Tulika P.
    Sharma, Vineet Kumar
    Warren, Wesley C.
    Wilson, Richard K.
    Suzuki, Yutaka
    Lawson, Daniel
    Hughes, Daniel Seth Toney
    Megy, Karyn
    Masiga, Daniel K.
    Mireji, Paul Odhiambo
    Hansen, Immo Alex
    Van Den Abbeele, Jan
    Benoit, Joshua B.
    Bourtzis, Kostas
    Obiero, George F O
    Robertson, Hugh M.
    Jones, Jeffery W.
    Zhou, Jingjiang
    Field, Linda M.
    Friedrich, Markus
    Nyanjom, Steven R G
    Telleria, Erich Loza
    Caljon, Guy
    Ribeiro, José M. C.
    Acosta-Serrano, Alvaro
    Ooi, Cherpheng
    Rose, Clair
    Price, David P.
    Haines, Lee Rafuse
    Christoffels, Alan G.
    Sim, Cheolho
    Pham, Daphne Q D
    Denlinger, David L.
    Geiser, Dawn L.
    Omedo, Irene A.
    Winzerling, Joy J.
    Peyton, Justin T.
    Marucha, Kevin K.
    Jonas, Mario
    Meuti, Megan E.
    Rawlings, Neil David
    Zhang, Qirui
    Macharia, Rosaline Wanjiru
    Michalkova, Veronika
    Dashti, Zahra Jalali Sefid
    Baumann, Aaron A.
    Gäde, Gerd
    Marco, Heather G.
    Caers, Jelle
    Schoofs, Liliane
    Riehle, Michael A.
    Hu, Wanqi
    Tu, Zhijian
    Tarone, Aaron M.
    Malacrida, Anna Rodolfa
    Kibet, Caleb K.
    Scolari, Francesca
    Koekemoer, J. J. O.
    Willis, Judith H.
    Gomulski, Ludvik M.
    Falchetto, Marco
    Scott, Maxwell J.
    Fu, Shuhua
    Sze, Singhoi
    Luiz, Thiago
    Weiss, Brian L.
    Walshe, Deirdre P.
    Wang, Jingwen
    Wamalwa, Mark
    Mwangi, Sarah
    Ramphul, Urvashi N.
    Snyder, Anna K.
    Brelsfoard, Corey L.
    Thomas, Gavin H.
    Tsiamis, George
    Arensburger, Peter
    Rio, Rita V M
    Macdonald, Sandy J.
    Panji, Sumir
    Kruger, Adele F.
    Benkahla, Alia
    Balyeidhusa, Apollo Simon Peter
    Msangi, Atway R.
    Okoro, Chinyere K.
    Stephens, Dawn
    Stanley, Eleanor J.
    Mpondo, Feziwe
    Wamwiri, Florence N.
    Mramba, Furaha
    Siwo, Geoffrey H.
    Githinji, George
    Harkins, Gordon William
    Murilla, Grace Adira
    Lehväslaiho, Heikki
    Malele, Imna I.
    Auma, Joanna Eseri
    Kinyua, Johnson K.
    Ouma, Johnson O.
    Okedi, Loyce M A
    Manga, Lucien
    Aslett, Martin A.
    Koffi, Mathurin
    Gaunt, Michael W.
    Makgamathe, Mmule
    Mulder, Nicola Jane
    Manangwa, Oliver
    Abila, Patrick P.
    Wincker, Patrick
    Gregory, Richard I.
    Bateta, Rosemary
    Sakate, Ryuichi
    Ommeh, Sheila
    Lehane, Stella M.
    Imanishi, Tadashi
    Osamor, Victor Chukwudi
    Kawahara, Yoshihiro
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2014-04-24
    Online Publication Date
    2014-04-24
    Print Publication Date
    2014-04-25
    Permanent link to this record
    http://hdl.handle.net/10754/563509
    
    Metadata
    Show full item record
    Abstract
    Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
    Citation
    Attardo, G. M., Abila, P. P., Auma, J. E., Baumann, A. A., Benoit, J. B., Brelsfoard, C. L., Ribeiro, J. M. C., Cotton, J. A., Pham, D. Q. D., Darby, A. C., Van Den Abbeele, J., Denlinger, D. L., Field, L. M., Nyanjom, S. R. G., Gaunt, M. W., Geiser, D. L., Gomulski, L. M., Haines, L. R., … Zhou, J.-J. (2014). Genome Sequence of the Tsetse Fly ( Glossina morsitans ): Vector of African Trypanosomiasis. Science, 344(6182), 380–386. https://doi.org/10.1126/science.1249656
    Sponsors
    The public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts," the European Union Cooperation in Science and Technology (COST) Action FA0701 "Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management," and a grant-in-aid for Scientific Research on Priority Areas "Comprehensive Genomics" from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.
    Publisher
    American Association for the Advancement of Science (AAAS)
    Journal
    Science
    DOI
    10.1126/science.1249656
    PubMed ID
    24763584
    PubMed Central ID
    PMC4077534
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077534
    http://europepmc.org/articles/pmc4077534?pdf=render
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.1249656
    Scopus Count
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    Articles; Biological and Environmental Science and Engineering (BESE) Division

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