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dc.contributor.authorSeyedmahmoud, Rasoul
dc.contributor.authorRainer, Alberto
dc.contributor.authorMozetic, Pamela
dc.contributor.authorMaria Giannitelli, Sara
dc.contributor.authorTrombetta, Marcella
dc.contributor.authorTraversa, Enrico
dc.contributor.authorLicoccia, Silvia
dc.contributor.authorRinaldi, Antonio
dc.date.accessioned2015-08-03T11:51:47Z
dc.date.available2015-08-03T11:51:47Z
dc.date.issued2014-03-20
dc.identifier.citationSeyedmahmoud, R., Rainer, A., Mozetic, P., Maria Giannitelli, S., Trombetta, M., Traversa, E., … Rinaldi, A. (2014). A primer of statistical methods for correlating parameters and properties of electrospun poly(l-lactide) scaffolds for tissue engineering-PART 1: Design of experiments. Journal of Biomedical Materials Research Part A, 103(1), 91–102. doi:10.1002/jbm.a.35153
dc.identifier.issn15493296
dc.identifier.doi10.1002/jbm.a.35153
dc.identifier.urihttp://hdl.handle.net/10754/563450
dc.description.abstractTissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-l-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young's modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed.
dc.publisherWiley
dc.subjectbiomaterials
dc.subjectelectrospinning
dc.subjectmechanical properties
dc.subjectparametric study
dc.subjectprocess control
dc.subjectstructure-property relations
dc.titleA primer of statistical methods for correlating parameters and properties of electrospun poly(l -lactide) scaffolds for tissue engineering-PART 1: Design of experiments
dc.typeArticle
dc.contributor.departmentKAUST Solar Center (KSC)
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentMaterials for Energy Conversion and Storage (MECS) Lab
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalJournal of Biomedical Materials Research Part A
dc.contributor.institutionUniv Roma Tor Vergata, Dept Chem Sci & Technol, I-00133 Rome, Italy
dc.contributor.institutionUniv Roma Tor Vergata, NAST Ctr, I-00133 Rome, Italy
dc.contributor.institutionUniv Campus Biomed Roma, Tissue Engn Lab, CIR Ctr Integrated Res, I-00128 Rome, Italy
dc.contributor.institutionENEA, CR Casaccia, I-00123 Rome, Italy
dc.contributor.institutionUniv Aquila, Int Res Ctr Math & Mech Complex Syst, I-04012 Cisterna Latina, LT, Italy
kaust.personTraversa, Enrico
dc.date.published-online2014-03-20
dc.date.published-print2015-01


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