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    A primer of statistical methods for correlating parameters and properties of electrospun poly(l -lactide) scaffolds for tissue engineering-PART 1: Design of experiments

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    Type
    Article
    Authors
    Seyedmahmoud, Rasoul
    Rainer, Alberto
    Mozetic, Pamela
    Maria Giannitelli, Sara
    Trombetta, Marcella
    Traversa, Enrico cc
    Licoccia, Silvia
    Rinaldi, Antonio
    KAUST Department
    KAUST Solar Center (KSC)
    Material Science and Engineering Program
    Materials for Energy Conversion and Storage (MECS) Lab
    Physical Science and Engineering (PSE) Division
    Date
    2014-03-20
    Online Publication Date
    2014-03-20
    Print Publication Date
    2015-01
    Permanent link to this record
    http://hdl.handle.net/10754/563450
    
    Metadata
    Show full item record
    Abstract
    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-l-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young's modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed.
    Citation
    Seyedmahmoud, R., Rainer, A., Mozetic, P., Maria Giannitelli, S., Trombetta, M., Traversa, E., … Rinaldi, A. (2014). A primer of statistical methods for correlating parameters and properties of electrospun poly(l-lactide) scaffolds for tissue engineering-PART 1: Design of experiments. Journal of Biomedical Materials Research Part A, 103(1), 91–102. doi:10.1002/jbm.a.35153
    Publisher
    Wiley
    Journal
    Journal of Biomedical Materials Research Part A
    DOI
    10.1002/jbm.a.35153
    ae974a485f413a2113503eed53cd6c53
    10.1002/jbm.a.35153
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program; KAUST Solar Center (KSC)

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