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    Multifunctional substrates of thin porous alumina for cell biosensors

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    Type
    Article
    Authors
    Toccafondi, Chiara
    Thorat, Sanjay B.
    La Rocca, Rosanna
    Scarpellini, Alice
    Salerno, Marco
    Dante, Silvia
    Das, Gobind cc
    KAUST Department
    Physical Science and Engineering (PSE) Division
    Date
    2014-02-27
    Online Publication Date
    2014-02-27
    Print Publication Date
    2014-10
    Permanent link to this record
    http://hdl.handle.net/10754/563406
    
    Metadata
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    Abstract
    We have fabricated anodic porous alumina from thin films (100/500 nm) of aluminium deposited on technological substrates of silicon/glass, and investigated the feasibility of this material as a surface for the development of analytical biosensors aiming to assess the status of living cells. To this goal, porous alumina surfaces with fixed pitch and variable pore size were analyzed for various functionalities. Gold coated (about 25 nm) alumina revealed surface enhanced Raman scattering increasing with the decrease in wall thickness, with factor up to values of approximately 104 with respect to the flat gold surface. Bare porous alumina was employed for micro-patterning and observation via fluorescence images of dye molecules, which demonstrated the surface capability for a drug-loading device. NIH-3T3 fibroblast cells were cultured in vitro and examined after 2 days since seeding, and no significant (P > 0.05) differences in their proliferation were observed on porous and non-porous materials. The effect on cell cultures of pore size in the range of 50–130 nm—with pore pitch of about 250 nm—showed no significant differences in cell viability and similar levels in all cases as on a control substrate. Future work will address combination of all above capabilities into a single device.
    Citation
    Toccafondi, C., Thorat, S., La Rocca, R., Scarpellini, A., Salerno, M., Dante, S., & Das, G. (2014). Multifunctional substrates of thin porous alumina for cell biosensors. Journal of Materials Science: Materials in Medicine, 25(10), 2411–2420. doi:10.1007/s10856-014-5178-4
    Publisher
    Springer Nature
    Journal
    Journal of Materials Science: Materials in Medicine
    DOI
    10.1007/s10856-014-5178-4
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10856-014-5178-4
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division

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