Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)

Chauke, Chesa G.; Arieff, Zainunisha; Kaur, Mandeep; Seier, Jürgen V.

Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)

Type

Article

Authors

Chauke, Chesa G.
Arieff, Zainunisha
Kaur, Mandeep
Seier, Jürgen V.

KAUST Department

Computational Bioscience Research Center (CBRC)

Online Publication Date

2014-02-01

Print Publication Date

2014-02

Date

2014-02-01

Abstract

Niacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.

Citation

Chauke, C. G., Arieff, Z., Kaur, M., & Seier, J. V. (2014). Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops). Lab Animal, 43(2), 58–62. doi:10.1038/laban.424