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dc.contributor.authorChauke, Chesa G.
dc.contributor.authorArieff, Zainunisha
dc.contributor.authorKaur, Mandeep
dc.contributor.authorSeier, Jürgen V.
dc.date.accessioned2015-08-03T11:46:19Z
dc.date.available2015-08-03T11:46:19Z
dc.date.issued2014-02-01
dc.identifier.issn00937355
dc.identifier.pmid24451360
dc.identifier.doi10.1038/laban.424
dc.identifier.urihttp://hdl.handle.net/10754/563347
dc.description.abstractNiacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.
dc.publisherSpringer Nature
dc.titleEffects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalLab Animal
dc.contributor.institutionMedical Research Council Primate Unit, Tygerberg, South Africa
dc.contributor.institutionBiotechnology Department, University of the Western Cape, Cape Town, South Africa
kaust.personKaur, Mandeep
dc.date.published-online2014-02-01
dc.date.published-print2014-02


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