Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)
Type
ArticleKAUST Department
Computational Bioscience Research Center (CBRC)Date
2014-02-01Online Publication Date
2014-02-01Print Publication Date
2014-02Permanent link to this record
http://hdl.handle.net/10754/563347
Metadata
Show full item recordAbstract
Niacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.Citation
Chauke, C. G., Arieff, Z., Kaur, M., & Seier, J. V. (2014). Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops). Lab Animal, 43(2), 58–62. doi:10.1038/laban.424Publisher
Springer NatureJournal
Lab AnimalPubMed ID
24451360ae974a485f413a2113503eed53cd6c53
10.1038/laban.424
Scopus Count
Related articles
- Effect of niacin on high-density lipoprotein apolipoprotein A-I kinetics in statin-treated patients with type 2 diabetes mellitus.
- Authors: Pang J, Chan DC, Hamilton SJ, Tenneti VS, Watts GF, Barrett PH
- Issue date: 2014 Feb
- Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials.
- Authors: Birjmohun RS, Hutten BA, Kastelein JJ, Stroes ES
- Issue date: 2005 Jan 18
- The facts behind niacin.
- Authors: Hochholzer W, Berg DD, Giugliano RP
- Issue date: 2011 Oct
- Efficacy and safety of combination of extended release niacin and atorvastatin in patients with low levels of high density lipoprotein cholesterol.
- Authors: Harikrishnan S, Rajeev E, Tharakan JA, Titus T, Ajit Kumar VK, Sivasankaran S, Krishnamoorthy KM, Nair K
- Issue date: 2008 May-Jun
- Niacin and lipoprotein(a): facts, uncertainties, and clinical considerations.
- Authors: Scanu AM, Bamba R
- Issue date: 2008 Apr 17