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dc.contributor.authorConchouso Gonzalez, David
dc.contributor.authorCastro, David
dc.contributor.authorKhan, Saif
dc.contributor.authorFoulds, Ian G.
dc.date.accessioned2015-08-03T11:43:33Z
dc.date.available2015-08-03T11:43:33Z
dc.date.issued2014-06-20
dc.identifier.citationConchouso, D., Castro, D., Khan, S. A., & Foulds, I. G. (2014). Three-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions. Lab on a Chip, 14(16), 3011. doi:10.1039/c4lc00379a
dc.identifier.issn14730197
dc.identifier.pmid24947654
dc.identifier.doi10.1039/c4lc00379a
dc.identifier.urihttp://hdl.handle.net/10754/563224
dc.description.abstractThis paper looks at the design, fabrication and characterization of stackable microfluidic emulsion generators, with coefficients of variation as low as ~6% and with production rates as high as ~1 L h-1. This work reports the highest throughput reported in the literature for a microfluidic device with simultaneous operation of liquid-liquid droplet generators. The device was achieved by stacking several layers of 128 flow-focusing droplet generators, organized in a circular array. These layers are interconnected via through-holes and fed with designated fractal distribution networks. The proposed layers were milled on poly(methylmethacrylate) (PMMA) sheets and the stack was thermo-compression bonded to create a three-dimensional device with a high density of generators and an integrated hydraulic manifold. The effect of stacking multiple layers was studied and the results show that fabrication accuracy has a greater impact on the dispersity of the emulsion than the addition of more layers to the stack. Particle crystallization of drugs was also demonstrated as a possible application of this technology in industry. © 2014 the Partner Organisations.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleThree-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions
dc.typeArticle
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentElectromechanical Microsystems & Polymer Integration Research Lab (EMPIRe)
dc.identifier.journalLab on a Chip
dc.contributor.institutionNational University of Singapore, Department of Chemical and Bimolecular Engineering, 4 Engineering Drive 4 E5-02-28, 117576 Singapore, Singapore
dc.contributor.institutionUniversity of British Columbia, Okanagan, Canada
kaust.personFoulds, Ian G.
kaust.personConchouso Gonzalez, David
kaust.personCastro, David


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