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    Three-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions

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    Type
    Article
    Authors
    Conchouso Gonzalez, David cc
    Castro, David cc
    Khan, Saif
    Foulds, Ian G.
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Electromechanical Microsystems & Polymer Integration Research Lab (EMPIRe)
    Date
    2014-06-20
    Permanent link to this record
    http://hdl.handle.net/10754/563224
    
    Metadata
    Show full item record
    Abstract
    This paper looks at the design, fabrication and characterization of stackable microfluidic emulsion generators, with coefficients of variation as low as ~6% and with production rates as high as ~1 L h-1. This work reports the highest throughput reported in the literature for a microfluidic device with simultaneous operation of liquid-liquid droplet generators. The device was achieved by stacking several layers of 128 flow-focusing droplet generators, organized in a circular array. These layers are interconnected via through-holes and fed with designated fractal distribution networks. The proposed layers were milled on poly(methylmethacrylate) (PMMA) sheets and the stack was thermo-compression bonded to create a three-dimensional device with a high density of generators and an integrated hydraulic manifold. The effect of stacking multiple layers was studied and the results show that fabrication accuracy has a greater impact on the dispersity of the emulsion than the addition of more layers to the stack. Particle crystallization of drugs was also demonstrated as a possible application of this technology in industry. © 2014 the Partner Organisations.
    Citation
    Conchouso, D., Castro, D., Khan, S. A., & Foulds, I. G. (2014). Three-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions. Lab on a Chip, 14(16), 3011. doi:10.1039/c4lc00379a
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    Lab on a Chip
    DOI
    10.1039/c4lc00379a
    PubMed ID
    24947654
    ae974a485f413a2113503eed53cd6c53
    10.1039/c4lc00379a
    Scopus Count
    Collections
    Articles; Electrical and Computer Engineering Program; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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