Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles
AuthorsGentile, Francesco T.
Coluccio, Maria Laura
Proietti Zaccaria, Remo
Di Fabrizio, Enzo M.
KAUST DepartmentMaterial Science and Engineering Program
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/563217
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AbstractSuper-hydrophobic surfaces are bio-inspired interfaces with a superficial texture that, in its most common evolution, is formed by a periodic lattice of silicon micro-pillars. Similar surfaces reveal superior properties compared to conventional flat surfaces, including very low friction coefficients. In this work, we modified meso-porous silicon micro-pillars to incorporate networks of metal nano-particles into the porous matrix. In doing so, we obtained a multifunctional-hierarchical system in which (i) at a larger micrometric scale, the super-hydrophobic pillars bring the molecules dissolved in an ultralow-concentration droplet to the active sites of the device, (ii) at an intermediate meso-scale, the meso-porous silicon film adsorbs the low molecular weight content of the solution and, (iii) at a smaller nanometric scale, the aggregates of silver nano-particles would measure the target molecules with unprecedented sensitivity. In the results, we demonstrated how this scheme can be utilized to isolate and detect small molecules in a diluted solution in very low abundance ranges. The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. © 2014 the Partner Organisations.
SponsorsThis work has been partially funded by the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013), from the Italian Minister of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques" (Project no. GR-2010-2320665), and the project "High throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (Project no. GR-2010-2311677), and from the Cariplo Foundation under the project "New Frontiers in Plasmonic Nano-sensing" (Grant no. 2011-0338).
PublisherRoyal Society of Chemistry (RSC)