"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes
Type
ArticleKAUST Department
Advanced Membranes and Porous Materials Research CenterAdvanced Nanofabrication, Imaging and Characterization Core Lab
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Core Labs
Environmental Science and Engineering Program
Imaging and Characterization Core Lab
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2014Permanent link to this record
http://hdl.handle.net/10754/563177
Metadata
Show full item recordAbstract
Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.Citation
Li, W., Deng, L., Moosa, B., Wang, G., Mashat, A., & M. Khashab, N. (2014). “Nail” and “comb” effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes. Biomaterials Science, 2(4), 476. doi:10.1039/c3bm60222bSponsors
This research is fully sponsored by King Abdullah University of Science and Technology (KAUST).Publisher
Royal Society of Chemistry (RSC)Journal
Biomaterials Scienceae974a485f413a2113503eed53cd6c53
10.1039/c3bm60222b