"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
Advanced Membranes and Porous Materials Research Center
Imaging and Characterization Core Lab
Biological and Environmental Sciences and Engineering (BESE) Division
Environmental Science and Engineering Program
Smart Hybrid Materials (SHMs) lab
Advanced Nanofabrication, Imaging and Characterization Core Lab
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AbstractThermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.
SponsorsThis research is fully sponsored by King Abdullah University of Science and Technology (KAUST).
PublisherRoyal Society of Chemistry (RSC)