Show simple item record

dc.contributor.authorGuo, Yong
dc.contributor.authorLi, Song
dc.contributor.authorLi, Wengang
dc.contributor.authorMoosa, Basem
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-08-03T11:37:16Z
dc.date.available2015-08-03T11:37:16Z
dc.date.issued2014
dc.identifier.issn20474830
dc.identifier.doi10.1039/c3bm60163c
dc.identifier.urihttp://hdl.handle.net/10754/563165
dc.description.abstractColloidal nanodiamonds (NDs) have emerged as highly versatile platforms for the controlled delivery of therapeutics, proteins, DNA, and other assorted biological agents. The most common mechanism of drug loading onto the ND surface depends mainly on electrostatic interactions. Although a few reports have been published on using NaCl salt to increase the drug loading onto NDs, no comprehensive mechanistic study with a wide range of anions and cations has been reported. In this work, the Hofmeister effect of inorganic salts and amino acids with different isoelectric points was employed to understand the mechanism of doxorubicin (DOXH+) loading onto NDs with different sizes. Inorganic salts including NaCl, NaNO3, Na2SO4, KCl, CaCl2, (NH4)2SO4 and amino acids with an isoelectric point above 7 (positively charged at neutral pH) increase the DOXH+ loading onto small size NDs (SNDs, 5-10 nm). On the other hand, amino acids with an isoelectric point below 7 (negatively charged at neutral pH) increase the DOXH+ loading onto large size NDs (LNDs, 80-100 nm). © 2014 The Royal Society of Chemistry.
dc.description.sponsorshipWe thank King Abdullah University of Science and Technology (KAUST) for the financial support.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleThe Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platforms
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentNumerical Porous Media SRI Center (NumPor)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalBiomater. Sci.
kaust.personGuo, Yong
kaust.personLi, Song
kaust.personLi, Wengang
kaust.personMoosa, Basem
kaust.personKhashab, Niveen M.


This item appears in the following Collection(s)

Show simple item record