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    The Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platforms

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    Type
    Article
    Authors
    Guo, Yong
    Li, Song cc
    Li, Wengang cc
    Moosa, Basem cc
    Khashab, Niveen M. cc
    KAUST Department
    Numerical Porous Media SRI Center (NumPor)
    Smart Hybrid Materials (SHMs) lab
    Advanced Membranes and Porous Materials Research Center
    Physical Sciences and Engineering (PSE) Division
    Chemical Science Program
    Date
    2014
    Permanent link to this record
    http://hdl.handle.net/10754/563165
    
    Metadata
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    Abstract
    Colloidal nanodiamonds (NDs) have emerged as highly versatile platforms for the controlled delivery of therapeutics, proteins, DNA, and other assorted biological agents. The most common mechanism of drug loading onto the ND surface depends mainly on electrostatic interactions. Although a few reports have been published on using NaCl salt to increase the drug loading onto NDs, no comprehensive mechanistic study with a wide range of anions and cations has been reported. In this work, the Hofmeister effect of inorganic salts and amino acids with different isoelectric points was employed to understand the mechanism of doxorubicin (DOXH+) loading onto NDs with different sizes. Inorganic salts including NaCl, NaNO3, Na2SO4, KCl, CaCl2, (NH4)2SO4 and amino acids with an isoelectric point above 7 (positively charged at neutral pH) increase the DOXH+ loading onto small size NDs (SNDs, 5-10 nm). On the other hand, amino acids with an isoelectric point below 7 (negatively charged at neutral pH) increase the DOXH+ loading onto large size NDs (LNDs, 80-100 nm). © 2014 The Royal Society of Chemistry.
    Sponsors
    We thank King Abdullah University of Science and Technology (KAUST) for the financial support.
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    Biomater. Sci.
    DOI
    10.1039/c3bm60163c
    ae974a485f413a2113503eed53cd6c53
    10.1039/c3bm60163c
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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