The Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platforms
Type
ArticleKAUST Department
Numerical Porous Media SRI Center (NumPor)Smart Hybrid Materials (SHMs) lab
Advanced Membranes and Porous Materials Research Center
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
Date
2014Permanent link to this record
http://hdl.handle.net/10754/563165
Metadata
Show full item recordAbstract
Colloidal nanodiamonds (NDs) have emerged as highly versatile platforms for the controlled delivery of therapeutics, proteins, DNA, and other assorted biological agents. The most common mechanism of drug loading onto the ND surface depends mainly on electrostatic interactions. Although a few reports have been published on using NaCl salt to increase the drug loading onto NDs, no comprehensive mechanistic study with a wide range of anions and cations has been reported. In this work, the Hofmeister effect of inorganic salts and amino acids with different isoelectric points was employed to understand the mechanism of doxorubicin (DOXH+) loading onto NDs with different sizes. Inorganic salts including NaCl, NaNO3, Na2SO4, KCl, CaCl2, (NH4)2SO4 and amino acids with an isoelectric point above 7 (positively charged at neutral pH) increase the DOXH+ loading onto small size NDs (SNDs, 5-10 nm). On the other hand, amino acids with an isoelectric point below 7 (negatively charged at neutral pH) increase the DOXH+ loading onto large size NDs (LNDs, 80-100 nm). © 2014 The Royal Society of Chemistry.Sponsors
We thank King Abdullah University of Science and Technology (KAUST) for the financial support.Publisher
Royal Society of Chemistry (RSC)Journal
Biomater. Sci.ae974a485f413a2113503eed53cd6c53
10.1039/c3bm60163c