Efficient SN2 fluorination of primary and secondary alkyl bromides by copper(I) fluoride complexes
KAUST DepartmentKAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
MetadataShow full item record
AbstractCopper(I) fluoride complexes ligated by phenanthroline derivatives have been synthesized and structurally characterized by X-ray crystallography. These complexes adopt as either ionic or neutral forms in the solid state, depending on the steric bulkiness of the substituent groups on the phenanthroline ligands. These complexes react with primary and secondary alkyl bromides to produce the corresponding alkyl fluorides in modest to good yields. This new method is compatible with a variety of important functional groups such as ether, thioether, amide, nitrile, methoxyl, hydroxyl, ketone, ester, and heterocycle moieties. © 2013 American Chemical Society.
SponsorsWe acknowledge the financial support from National Natural Science Foundation of China (21072030), Research Fund for the Doctoral Program of Higher Education of China (No. 20123514110003), SRF for ROCS, SEM (J20121707), the Science Foundation of the Fujian Province, China (2013J01040), and Fuzhou University (022318, 022494) to Z.W. and King Abdullah University of Science and Technology to K.-W.H.
PublisherAmerican Chemical Society (ACS)
Is Supplemented ByLiu, Y., Chen, C., Li, H., Huang, K.-W., Tan, J., & Weng, Z. (2014). CCDC 949811: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc10wc2b
Liu, Y., Chen, C., Li, H., Huang, K.-W., Tan, J., & Weng, Z. (2014). CCDC 949812: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc10wc3c
Liu, Y., Chen, C., Li, H., Huang, K.-W., Tan, J., & Weng, Z. (2014). CCDC 949813: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc10wc4d