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dc.contributor.authorFedoroff, Nina V.
dc.date.accessioned2015-08-03T11:15:19Z
dc.date.available2015-08-03T11:15:19Z
dc.date.issued2013-08-21
dc.identifier.isbn9781627035675
dc.identifier.issn10643745
dc.identifier.doi10.1007/978-1-62703-568-2-13
dc.identifier.urihttp://hdl.handle.net/10754/562915
dc.description.abstractThe CACTA transposons, so named for a highly conserved motif at element ends, comprise one of the most abundant superfamilies of Class 2 (cut-and-paste) plant transposons. CACTA transposons characteristically include subterminal sequences of several hundred nucleotides containing closely spaced direct and inverted repeats of a short, conserved sequence of 14-15 bp. The Supressor-mutator (Spm) transposon, identified and subjected to detailed genetic analysis by Barbara McClintock, remains the paradigmatic element of the CACTA family. The Spm transposon encodes two proteins required for transposition, the transposase (TnpD) and a regulatory protein (TnpA) that binds to the subterminal repeats. Spm expression is subject to both genetic and epigenetic regulation. The Spm-encoded TnpA serves as an activator of the epigenetically inactivated, methylated Spm, stimulating both transient and heritable activation of the transposon. TnpA also serves as a negative regulator of the demethylated active element promoter and is required, in addition to the TnpD, for transposition. © Springer Science+Business Media, New York 2013.
dc.publisherHumana Press
dc.subjectCACTA elements
dc.subjectepigenetic regulation
dc.subjectSpm
dc.subjectSuppressor-mutator
dc.subjectTnpA
dc.subjectTnpD
dc.subjecttransposition
dc.subjecttransposon
dc.titleMolecular genetics and epigenetics of CACTA elements
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalMethods in Molecular Biology
dc.contributor.institutionHuck Institutes of the Life Sciences, Penn State University, University Park, PA, United States
kaust.personFedoroff, Nina V.


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