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    A magnetic biosensor system for detection of E. coli

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    Type
    Article
    Authors
    Li, Fuquan cc
    Kosel, Jürgen cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Sensing, Magnetism and Microsystems Lab
    Date
    2013-07
    Permanent link to this record
    http://hdl.handle.net/10754/562854
    
    Metadata
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    Abstract
    This work describes a device for detecting E. coli bacteria by manipulating superparamagnetic beads to a sensing area and immobilizing them in a trapping well. The trapping well replaces the biochemical immobilization layer, which is commonly used in magnetic biosensor systems. A concept exploiting the volume difference between bare magnetic beads and magnetic bead-bioanalyte compounds is utilized to detect E. coli bacteria. Trapped beads are detected by the help of a tunnel magneto-resistive sensor. Frequency modulation is employed, in order to increase the signal-to-noise ratio, enabling the detection of individual superparamagnetic beads of 2.8 μm in diameter. Replacing the biochemical immobilization layer by the trapping well greatly simplifies the detection process. After applying the mixture of E. coli and magnetic beads to the biosensor system, bacteria detection is achieved in a single step, within a few minutes. © 2013 IEEE.
    Citation
    Li, F., & Kosel, J. (2013). A Magnetic Biosensor System for Detection of E. coli. IEEE Transactions on Magnetics, 49(7), 3492–3495. doi:10.1109/tmag.2013.2244580
    Publisher
    Institute of Electrical and Electronics Engineers (IEEE)
    Journal
    IEEE Transactions on Magnetics
    DOI
    10.1109/TMAG.2013.2244580
    ae974a485f413a2113503eed53cd6c53
    10.1109/TMAG.2013.2244580
    Scopus Count
    Collections
    Articles; Electrical and Computer Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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