• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguideTheses and Dissertations LibguideSubmit an Item

    Statistics

    Display statistics

    Human NK cells selective targeting of colon cancer-initiating cells: A role for natural cytotoxicity receptors and MHC class i molecules

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Type
    Article
    Authors
    Tallerico, Rossana
    Todaro, Matilde
    Di Franco, Simone
    MacCalli, Cristina
    Garofalo, Cinzia
    Sottile, Rosa
    Palmieri, Camillo
    Tirinato, Luca cc
    Pangigadde, Pradeepa N.
    La Rocca, Rosanna
    Mandelboim, Ofer
    Stassi, Giorgio
    Di Fabrizio, Enzo M. cc
    Parmiani, Giorgio
    Moretta, Alessandro
    Dieli, Francesco
    Kãrre, Klas
    Carbone, Ennio
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2013-01-23
    Online Publication Date
    2013-01-23
    Print Publication Date
    2013-03-01
    Permanent link to this record
    http://hdl.handle.net/10754/562617
    
    Metadata
    Show full item record
    Abstract
    Tumor cell populations have been recently proposed to be composed of two compartments: tumor-initiating cells characterized by a slow and asymmetrical growth, and the "differentiated" cancer cells with a fast and symmetrical growth. Cancer stem cells or cancer-initiating cells (CICs) play a crucial role in tumor recurrence. The resistance of CICs to drugs and irradiation often allows them to survive traditional therapy. NK cells are potent cytotoxic lymphocytes that can recognize tumor cells. In this study, we have analyzed the NK cell recognition of tumor target cells derived from the two cancer cell compartments of colon adenocarcinoma lesions. Our data demonstrate that freshly purified allogeneic NK cells can recognize and kill colorectal carcinoma- derived CICs whereas the non-CIC counterpart of the tumors (differentiated tumor cells), either autologous or allogeneic, is less susceptible to NK cells. This difference in the NK cell susceptibility correlates with higher expression on CICs of ligands for NKp30 and NKp44 in the natural cytotoxicity receptor (NCR) group of activating NK receptors. In contrast, CICs express lower levels of MHC class I, known to inhibit NK recognition, on their surface than do the "differentiated" tumor cells. These data have been validated by confocal microscopy where NCR ligands and MHC class I molecule membrane distribution have been analyzed. Moreover, NK cell receptor blockade in cytotoxicity assays demonstrates that NCRs play a major role in the recognition of CIC targets. This study strengthens the idea that biology-based therapy harnessing NK cells could be an attractive opportunity in solid tumors. Copyright © 2013 by The American Association of Immunologists, Inc. All rights reserved.
    Citation
    Tallerico, R., Todaro, M., Di Franco, S., Maccalli, C., Garofalo, C., Sottile, R., … Carbone, E. (2013). Human NK Cells Selective Targeting of Colon Cancer–Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules. The Journal of Immunology, 190(5), 2381–2390. doi:10.4049/jimmunol.1201542
    Sponsors
    This work was supported by grants from the Associazione Italiana per la Ricerca sul Cancro, as well as by Axel Wenner-Gren Foundation Grant AIRC 10189 (to E. C.) and by Grants AIRC IG 8730 (to G. S.) and AIRC IG 10254 (to M. T.). R. S. is a recipient of a fellowship awarded by the Programma Operativo Regionale Calabria Fondo Sociale Europeo (2007-2013). S. D. F. is a Ph.D. student in the International Ph.D. Program in Immunopharmacology at the University of Palermo. R. T. is a Ph.D. student in the International Ph.D. Program in Molecular Oncology, Experimental Immunology and Development of Innovative Therapies.
    Publisher
    The American Association of Immunologists
    Journal
    The Journal of Immunology
    DOI
    10.4049/jimmunol.1201542
    PubMed ID
    23345327
    ae974a485f413a2113503eed53cd6c53
    10.4049/jimmunol.1201542
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

    entitlement

    Related articles

    • Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences.
    • Authors: Hecht ML, Rosental B, Horlacher T, Hershkovitz O, De Paz JL, Noti C, Schauer S, Porgador A, Seeberger PH
    • Issue date: 2009 Feb
    • NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
    • Authors: Castriconi R, Daga A, Dondero A, Zona G, Poliani PL, Melotti A, Griffero F, Marubbi D, Spaziante R, Bellora F, Moretta L, Moretta A, Corte G, Bottino C
    • Issue date: 2009 Mar 15
    • Anti-cancer activity and mechanistic features of a NK cell activating molecule.
    • Authors: Kim HR, Lee KH, Park SJ, Kim SY, Yang YK, Tae J, Kim J
    • Issue date: 2009 Oct
    • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
    • Authors: Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L
    • Issue date: 2001
    • Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.
    • Authors: Koch J, Steinle A, Watzl C, Mandelboim O
    • Issue date: 2013 Apr
    DSpace software copyright © 2002-2022  DuraSpace
    Quick Guide | Contact Us | KAUST University Library
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.