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dc.contributor.authorReiner, Thomas
dc.contributor.authorJantke, Dominik
dc.contributor.authorMiao, Xiaohe
dc.contributor.authorMarziale, Alexander N.
dc.contributor.authorKiefer, Florian J.
dc.contributor.authorEppinger, Jörg
dc.date.accessioned2015-08-03T10:40:38Z
dc.date.available2015-08-03T10:40:38Z
dc.date.issued2013
dc.identifier.issn14779226
dc.identifier.pmid23632736
dc.identifier.doi10.1039/c3dt50589h
dc.identifier.urihttp://hdl.handle.net/10754/562506
dc.description.abstractThe reaction of (S)-2,5-dihydrophenylalanine 1 with ruthenium(iii) chloride yields the μ-chloro-bridged dimeric η6-phenylalanine ethyl ester complex 3, which can be converted into the monomeric analogue, η6:κ1-phenylalanine ethyl ester complex 12, under basic conditions. Studies were carried out to determine the stability and reactivity of complexes bearing η6- and η6: κ1-chelating phenylalanine ligands under various conditions. Reaction of 3 with ethylenediamine derivatives N-p-tosylethylenediamine or 1,4-di-N-p-tosylethylenediamine results in the formation of monomeric η6:κ1-phenylalanine ethyl ester complexes 14 and 15, which could be saponified yielding complexes 16 and 17 without changing the inner coordination sphere of the metal centre. The structure of η6:κ1-phenylalanine complex 17 and an N-κ1-phenylalanine complex 13 resulting from the reaction of 3 with an excess of pyridine were confirmed by X-ray crystallography. © 2013 The Royal Society of Chemistry.
dc.description.sponsorshipThe authors thank Dr Andreas O. Frank for help with NMR spectra and both Prof. Dr Horst Kessler and Prof. Dr Thomas F. Fassler for helpful discussions. This work was supported by KAUST-GCR (FIC/2010/07) and the KAUST baseline fund (J. E.). We thank the Elitenetzwerk Bayern (graduate fellowship for T. R. and A. N. M.) and the IDK NanoCat for funding.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titlePhenylalanine-a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(ii) centres
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentBiological & Organometallic Catalysis Laboratories
dc.identifier.journalDalton Transactions
dc.contributor.institutionTechnische Universität München, Department Chemie, Lichtenbergstr. 4, D-85747 Garching, Germany
dc.contributor.institutionDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States
kaust.personMiao, Xiaohe
kaust.personEppinger, Jörg
kaust.personJantke, Dominik
kaust.personMarziale, Alexander N.
dc.relation.isSupplementedByReiner, T., Jantke, D., Miao, X.-H., Marziale, A. N., Kiefer, F. J., & Eppinger, J. (2013). CCDC 721713: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccs7022
dc.relation.isSupplementedByDOI:10.5517/ccs7022
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624608
dc.relation.isSupplementedByReiner, T., Jantke, D., Miao, X.-H., Marziale, A. N., Kiefer, F. J., & Eppinger, J. (2013). CCDC 721712: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccs7011
dc.relation.isSupplementedByDOI:10.5517/ccs7011
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624607


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