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    Superhydrophobic surfaces allow probing of exosome self organization using X-ray scattering

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    Type
    Article
    Authors
    Accardo, Angelo
    Tirinato, Luca cc
    Altamura, Davide
    Sibillano, Teresa
    Giannini, Cinzia
    Riekel, Christian
    Di Fabrizio, Enzo M. cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2013
    Permanent link to this record
    http://hdl.handle.net/10754/562480
    
    Metadata
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    Abstract
    Drops of exosome dispersions from healthy epithelial colon cell line and colorectal cancer cells were dried on a superhydrophobic PMMA substrate. The residues were studied by small- and wide-angle X-ray scattering using both a synchrotron radiation micrometric beam and a high-flux table-top X-ray source. Structural differences between healthy and cancerous cells were detected in the lamellar lattices of the exosome macro-aggregates. © 2013 The Royal Society of Chemistry.
    Sponsors
    The authors are grateful for the SEED project "X-ray synchrotron class rotating anode microsource for the structural micro imaging of nanomaterials and engineered biotissues (XMI-LAB)" - IIT Protocol no. 21537 of 23/12/2009 and the FIRB 2009/2010 project "Rete integrata per la Nano Medicina (RINAME)" - RBAP114AMK_006. Rocco Lassandro and Giuseppe Chita are acknowledged for the technical support.
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    Nanoscale
    DOI
    10.1039/c3nr34032e
    PubMed ID
    23426504
    ae974a485f413a2113503eed53cd6c53
    10.1039/c3nr34032e
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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