Superhydrophobic surfaces allow probing of exosome self organization using X-ray scattering

Type
Article
Authors
Accardo, Angelo
Tirinato, Luca cc
Altamura, Davide
Sibillano, Teresa
Giannini, Cinzia
Riekel, Christian
Di Fabrizio, Enzo M. cc
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Physical Sciences and Engineering (PSE) Division
Materials Science and Engineering Program
Date
2013

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Abstract
Drops of exosome dispersions from healthy epithelial colon cell line and colorectal cancer cells were dried on a superhydrophobic PMMA substrate. The residues were studied by small- and wide-angle X-ray scattering using both a synchrotron radiation micrometric beam and a high-flux table-top X-ray source. Structural differences between healthy and cancerous cells were detected in the lamellar lattices of the exosome macro-aggregates. © 2013 The Royal Society of Chemistry.
Sponsors
The authors are grateful for the SEED project "X-ray synchrotron class rotating anode microsource for the structural micro imaging of nanomaterials and engineered biotissues (XMI-LAB)" - IIT Protocol no. 21537 of 23/12/2009 and the FIRB 2009/2010 project "Rete integrata per la Nano Medicina (RINAME)" - RBAP114AMK_006. Rocco Lassandro and Giuseppe Chita are acknowledged for the technical support.
Publisher
Royal Society of Chemistry (RSC)
Journal
Nanoscale
ISSN
20403364
DOI
10.1039/c3nr34032e
PubMed ID
23426504
Handle URI
http://hdl.handle.net/10754/562480
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