Superhydrophobic surfaces allow probing of exosome self organization using X-ray scattering
Di Fabrizio, Enzo M.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Physical Sciences and Engineering (PSE) Division
Materials Science and Engineering Program
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AbstractDrops of exosome dispersions from healthy epithelial colon cell line and colorectal cancer cells were dried on a superhydrophobic PMMA substrate. The residues were studied by small- and wide-angle X-ray scattering using both a synchrotron radiation micrometric beam and a high-flux table-top X-ray source. Structural differences between healthy and cancerous cells were detected in the lamellar lattices of the exosome macro-aggregates. © 2013 The Royal Society of Chemistry.
SponsorsThe authors are grateful for the SEED project "X-ray synchrotron class rotating anode microsource for the structural micro imaging of nanomaterials and engineered biotissues (XMI-LAB)" - IIT Protocol no. 21537 of 23/12/2009 and the FIRB 2009/2010 project "Rete integrata per la Nano Medicina (RINAME)" - RBAP114AMK_006. Rocco Lassandro and Giuseppe Chita are acknowledged for the technical support.
PublisherRoyal Society of Chemistry (RSC)
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