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    Characterization of internal structure of hydrated agar and gelatin matrices by cryo-SEM

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    Type
    Article
    Authors
    Rahbani, Janane
    Behzad, Ali Reza
    Khashab, Niveen M. cc
    Al-Ghoul, Mazen
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Advanced Nanofabrication, Imaging and Characterization Core Lab
    Chemical Science Program
    Core Labs
    Imaging and Characterization Core Lab
    Numerical Porous Media SRI Center (NumPor)
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2012-12-26
    Online Publication Date
    2012-12-26
    Print Publication Date
    2013-02
    Permanent link to this record
    http://hdl.handle.net/10754/562467
    
    Metadata
    Show full item record
    Abstract
    There has been a considerable interest in recent years in developing polymer gel matrices for many important applications such as 2DE for quantization and separation of a variety of proteins and drug delivery system to control the release of active agents. However, a well-defined knowledge of the ultrastructures of the gels has been elusive. In this study, we report the characterization of two different polymers used in 2DE: Gelatin, a naturally occurring polymer derived from collagen (protein) and agar, a polymer of polysaccharide (sugar) origin. Low-temperature SEM is used to examine the internal structure of these gels in their frozen natural hydrated states. Results of this study show that both polymers have an array of hollow cells that resembles honeycomb structures. While agar pores are almost circular, the corresponding Gaussian curve is very broad exhibiting a range of radii from nearly 370 to 700 nm. Gelatin pores are smaller and more homogeneous reflecting a narrower distribution from nearly 320 to 650 nm. Overall, these ultrastructural findings could be used to correlate with functions of the polymers. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Citation
    Rahbani, J., Behzad, A. R., Khashab, N. M., & Al-Ghoul, M. (2012). Characterization of internal structure of hydrated agar and gelatin matrices by cryo-SEM. ELECTROPHORESIS, 34(3), 405–408. doi:10.1002/elps.201200434
    Sponsors
    The authors gratefully acknowledge the funding provided by the American University of Beirut Research Board and by the Lebanese National Council for Scientific Research (LCNSR).
    Publisher
    Wiley
    Journal
    ELECTROPHORESIS
    DOI
    10.1002/elps.201200434
    PubMed ID
    23161518
    ae974a485f413a2113503eed53cd6c53
    10.1002/elps.201200434
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Imaging and Characterization Core Lab; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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