An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides

Type
Article
Authors
Weng, Zhiqiang
He, Weiming
Chen, Chaohuang
Lee, Richmond
Tan, Davin
Lai, Zhiping cc
Kong, Dedao
Yuan, Yaofeng
Huang, Kuo-Wei cc
KAUST Department
Physical Sciences and Engineering (PSE) Division
Chemical and Biological Engineering Program
Advanced Membranes and Porous Materials Research Center
Chemical Science Program
KAUST Catalysis Center (KCC)
HCL
Date
2012-12-12

Metadata
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Abstract
A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF 3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Sponsors
We thank Prof. John Hartwig for useful discussions. The financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and KAUST to K.-W.H. are acknowledged.
Publisher
Wiley-Blackwell
Journal
Angewandte Chemie International Edition
ISSN
14337851
DOI
10.1002/anie.201208432
PubMed ID
23239429
Handle URI
http://hdl.handle.net/10754/562457
Is Supplemented By
Weng, Z., He, W., Chen, C., Lee, R., Tan, D., Lai, Z., … Huang, K.-W. (2013). CCDC 900614: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccz752f
DOI:10.5517/ccz752f
HANDLE:http://hdl.handle.net/10754/624751
Weng, Z., He, W., Chen, C., Lee, R., Tan, D., Lai, Z., … Huang, K.-W. (2013). CCDC 900613: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccz751d
DOI:10.5517/ccz751d
HANDLE:http://hdl.handle.net/10754/624750
Weng, Z., He, W., Chen, C., Lee, R., Tan, D., Lai, Z., … Huang, K.-W. (2013). CCDC 900612: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccz750c
DOI:10.5517/ccz750c
HANDLE:http://hdl.handle.net/10754/624749
Weng, Z., He, W., Chen, C., Lee, R., Tan, D., Lai, Z., … Huang, K.-W. (2013). CCDC 900611: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccz74z9
DOI:10.5517/ccz74z9
HANDLE:http://hdl.handle.net/10754/624748
Collections
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Chemical and Biological Engineering Program; KAUST Catalysis Center (KCC)