An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Chemical and Biological Engineering Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Online Publication Date2012-12-12
Print Publication Date2013-01-28
Permanent link to this recordhttp://hdl.handle.net/10754/562457
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AbstractA series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF 3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
SponsorsWe thank Prof. John Hartwig for useful discussions. The financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and KAUST to K.-W.H. are acknowledged.