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dc.contributor.authorKumar, Kewal
dc.contributor.authorSagar, Sunil
dc.contributor.authorEsau, Luke
dc.contributor.authorKaur, Mandeep
dc.contributor.authorKumar, Vipan
dc.date.accessioned2015-08-03T10:38:20Z
dc.date.available2015-08-03T10:38:20Z
dc.date.issued2012-12
dc.identifier.issn02235234
dc.identifier.pmid23124212
dc.identifier.doi10.1016/j.ejmech.2012.10.008
dc.identifier.urihttp://hdl.handle.net/10754/562442
dc.description.abstractThe present manuscript describes the synthesis of uracil-isatin hybrids via azide-alkyne cycloadditions and their cytotoxic evaluation against three human cancer cell lines viz. HeLa (cervix), MCF-7 (breast) and DU145 (prostate) using MTT assay. The evaluation studies revealed the dependence of cytotoxicity on C-5 substituents of both uracil and isatin as well as the alkyl chain length with compounds 6g and 6k showing IC50 values 18.21 and 13.90 μM respectively against DU145 cell lines. Most of the synthesized conjugates exhibited considerable selectivity against MCF-7 and DU145 cell lines. © 2012 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipFinancial assistance from Department of Science and Technology, New Delhi under Innovation in Science Pursuit for Inspired Research (INSPIRE) Fellowship (KK) is gratefully acknowledged.
dc.publisherElsevier BV
dc.subject1H-1,2,3-Triazole
dc.subjectAnti-cancer evaluation
dc.subjectClick chemistry
dc.subjectStructure-activity relationship
dc.subjectUracil-isatin conjugates
dc.titleSynthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentTechnology Transfer
dc.identifier.journalEuropean Journal of Medicinal Chemistry
dc.contributor.institutionDepartment of Chemistry, Guru Nanak Dev University, Amritsar 143005, India
kaust.personSagar, Sunil
kaust.personEsau, Luke
kaust.personKaur, Mandeep


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