Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation
Type
ArticleKAUST Department
Computational Bioscience Research Center (CBRC)Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Technology Transfer
Date
2012-12Permanent link to this record
http://hdl.handle.net/10754/562442
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Show full item recordAbstract
The present manuscript describes the synthesis of uracil-isatin hybrids via azide-alkyne cycloadditions and their cytotoxic evaluation against three human cancer cell lines viz. HeLa (cervix), MCF-7 (breast) and DU145 (prostate) using MTT assay. The evaluation studies revealed the dependence of cytotoxicity on C-5 substituents of both uracil and isatin as well as the alkyl chain length with compounds 6g and 6k showing IC50 values 18.21 and 13.90 μM respectively against DU145 cell lines. Most of the synthesized conjugates exhibited considerable selectivity against MCF-7 and DU145 cell lines. © 2012 Elsevier Masson SAS. All rights reserved.Citation
Kumar, K., Sagar, S., Esau, L., Kaur, M., & Kumar, V. (2012). Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil–isatin conjugates and their cytotoxic evaluation. European Journal of Medicinal Chemistry, 58, 153–159. doi:10.1016/j.ejmech.2012.10.008Sponsors
Financial assistance from Department of Science and Technology, New Delhi under Innovation in Science Pursuit for Inspired Research (INSPIRE) Fellowship (KK) is gratefully acknowledged.Publisher
Elsevier BVPubMed ID
23124212ae974a485f413a2113503eed53cd6c53
10.1016/j.ejmech.2012.10.008
Scopus Count
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