Preparation of porous polymer monoliths featuring enhanced surface coverage with gold nanoparticles
KAUST DepartmentChemical Science Program
Office of the VP
Physical Science and Engineering (PSE) Division
Embargo End Date2014-04-11
Permanent link to this recordhttp://hdl.handle.net/10754/562343
MetadataShow full item record
AbstractA new approach to the preparation of porous polymer monoliths with enhanced coverage of pore surface with gold nanoparticles has been developed. First, a generic poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was reacted with cystamine followed by the cleavage of its disulfide bonds with tris(2-carboxylethyl)phosphine, which liberated the desired thiol groups. Dispersions of gold nanoparticles with sizes varying from 5 to 40. nm were then pumped through the functionalized monoliths. The materials were then analyzed using both energy dispersive X-ray spectroscopy and thermogravimetric analysis. We found that the quantity of attached gold was dependent on the size of nanoparticles, with the maximum attachment of more than 60. wt% being achieved with 40. nm nanoparticles. Scanning electron micrographs of the cross sections of all the monoliths revealed the formation of a non-aggregated, homogenous monolayer of nanoparticles. The surface of the bound gold was functionalized with 1-octanethiol and 1-octadecanethiol, and these monolithic columns were used successfully for the separations of proteins in reversed phase mode. The best separations were obtained using monoliths modified with 15, 20, and 30. nm nanoparticles since these sizes produced the most dense coverage of pore surface with gold. © 2012 Elsevier B.V.
SponsorsAll experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. The financial support of Y.L. and J.F. by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.
JournalJournal of Chromatography A
PubMed Central IDPMC3424317
- Polymer monoliths with exchangeable chemistries: use of gold nanoparticles as intermediate ligands for capillary columns with varying surface functionalities.
- Authors: Cao Q, Xu Y, Liu F, Svec F, Fréchet JM
- Issue date: 2010 Sep 1
- On-column enrichment and surface-enhanced Raman scattering detection in nanoparticles functionalized porous capillary monolith.
- Authors: Jiang Q, Zeng T, Yang S, Chen Q, Chen L, Ye Y, Zhou J, Xu S
- Issue date: 2015 Apr 15
- Silver-coated monolithic columns for separation in radiopharmaceutical applications.
- Authors: Sedlacek O, Kucka J, Svec F, Hruby M
- Issue date: 2014 Apr
- Incorporation of metal-organic framework HKUST-1 into porous polymer monolithic capillary columns to enhance the chromatographic separation of small molecules.
- Authors: Yang S, Ye F, Lv Q, Zhang C, Shen S, Zhao S
- Issue date: 2014 Sep 19