Preparation of porous polymer monoliths featuring enhanced surface coverage with gold nanoparticles
Type
ArticleKAUST Department
Chemical Science ProgramOffice of the VP
Physical Science and Engineering (PSE) Division
Date
2012-04-11Embargo End Date
2014-04-11Permanent link to this record
http://hdl.handle.net/10754/562343
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Show full item recordAbstract
A new approach to the preparation of porous polymer monoliths with enhanced coverage of pore surface with gold nanoparticles has been developed. First, a generic poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was reacted with cystamine followed by the cleavage of its disulfide bonds with tris(2-carboxylethyl)phosphine, which liberated the desired thiol groups. Dispersions of gold nanoparticles with sizes varying from 5 to 40. nm were then pumped through the functionalized monoliths. The materials were then analyzed using both energy dispersive X-ray spectroscopy and thermogravimetric analysis. We found that the quantity of attached gold was dependent on the size of nanoparticles, with the maximum attachment of more than 60. wt% being achieved with 40. nm nanoparticles. Scanning electron micrographs of the cross sections of all the monoliths revealed the formation of a non-aggregated, homogenous monolayer of nanoparticles. The surface of the bound gold was functionalized with 1-octanethiol and 1-octadecanethiol, and these monolithic columns were used successfully for the separations of proteins in reversed phase mode. The best separations were obtained using monoliths modified with 15, 20, and 30. nm nanoparticles since these sizes produced the most dense coverage of pore surface with gold. © 2012 Elsevier B.V.Citation
Lv, Y., Alejandro, F. M., Fréchet, J. M. J., & Svec, F. (2012). Preparation of porous polymer monoliths featuring enhanced surface coverage with gold nanoparticles. Journal of Chromatography A, 1261, 121–128. doi:10.1016/j.chroma.2012.04.007Sponsors
All experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. The financial support of Y.L. and J.F. by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.Publisher
Elsevier BVJournal
Journal of Chromatography APubMed ID
22542442PubMed Central ID
PMC3424317Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424317http://europepmc.org/articles/pmc3424317?pdf=render
ae974a485f413a2113503eed53cd6c53
10.1016/j.chroma.2012.04.007
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