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    Preparation of porous polymer monoliths featuring enhanced surface coverage with gold nanoparticles

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    Type
    Article
    Authors
    Lv, Yongqin
    Alejandro, Fernando Maya
    Frechet, Jean cc
    Švec, František
    KAUST Department
    Chemical Science Program
    Office of the VP
    Physical Science and Engineering (PSE) Division
    Date
    2012-04-11
    Embargo End Date
    2014-04-11
    Permanent link to this record
    http://hdl.handle.net/10754/562343
    
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    Abstract
    A new approach to the preparation of porous polymer monoliths with enhanced coverage of pore surface with gold nanoparticles has been developed. First, a generic poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was reacted with cystamine followed by the cleavage of its disulfide bonds with tris(2-carboxylethyl)phosphine, which liberated the desired thiol groups. Dispersions of gold nanoparticles with sizes varying from 5 to 40. nm were then pumped through the functionalized monoliths. The materials were then analyzed using both energy dispersive X-ray spectroscopy and thermogravimetric analysis. We found that the quantity of attached gold was dependent on the size of nanoparticles, with the maximum attachment of more than 60. wt% being achieved with 40. nm nanoparticles. Scanning electron micrographs of the cross sections of all the monoliths revealed the formation of a non-aggregated, homogenous monolayer of nanoparticles. The surface of the bound gold was functionalized with 1-octanethiol and 1-octadecanethiol, and these monolithic columns were used successfully for the separations of proteins in reversed phase mode. The best separations were obtained using monoliths modified with 15, 20, and 30. nm nanoparticles since these sizes produced the most dense coverage of pore surface with gold. © 2012 Elsevier B.V.
    Citation
    Lv, Y., Alejandro, F. M., Fréchet, J. M. J., & Svec, F. (2012). Preparation of porous polymer monoliths featuring enhanced surface coverage with gold nanoparticles. Journal of Chromatography A, 1261, 121–128. doi:10.1016/j.chroma.2012.04.007
    Sponsors
    All experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. The financial support of Y.L. and J.F. by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.
    Publisher
    Elsevier BV
    Journal
    Journal of Chromatography A
    DOI
    10.1016/j.chroma.2012.04.007
    PubMed ID
    22542442
    PubMed Central ID
    PMC3424317
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424317
    http://europepmc.org/articles/pmc3424317?pdf=render
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.chroma.2012.04.007
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program

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