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dc.contributor.authorKöser, Claudio U.
dc.contributor.authorNiemann, Stefan
dc.contributor.authorSummers, David K.
dc.contributor.authorArcher, John A.C.
dc.date.accessioned2015-08-03T09:47:17Z
dc.date.available2015-08-03T09:47:17Z
dc.date.issued2012-06
dc.identifier.issn15671348
dc.identifier.pmid21723422
dc.identifier.doi10.1016/j.meegid.2011.06.011
dc.identifier.urihttp://hdl.handle.net/10754/562208
dc.description.abstractSince its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..
dc.description.sponsorshipClaudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.
dc.publisherElsevier BV
dc.subjectAnnotation errors
dc.subjectIsolate variation
dc.subjectMycobacterium tuberculosis H37Rv
dc.subjectSequencing errors
dc.titleOverview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalInfection, Genetics and Evolution
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom
dc.contributor.institutionMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany
kaust.personArcher, John A.C.


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