Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Type
Article
Authors
Köser, Claudio U.
Niemann, Stefan
Summers, David K.
Archer, John A.C. cc
KAUST Department
Computational Bioscience Research Center (CBRC)
Date
2012-06
Permanent link to this record
http://hdl.handle.net/10754/562208

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Abstract
Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..
Citation
Köser, C. U., Niemann, S., Summers, D. K., & Archer, J. A. C. (2012). Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates. Infection, Genetics and Evolution, 12(4), 807–810. doi:10.1016/j.meegid.2011.06.011
Sponsors
Claudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.
Publisher
Elsevier BV
Journal
Infection, Genetics and Evolution
DOI
10.1016/j.meegid.2011.06.011
PubMed ID
21723422
Collections
Articles; Computational Bioscience Research Center (CBRC)