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[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling

dc.contributor.authorChartoire, Anthony
dc.contributor.authorLesieur, Mathieu
dc.contributor.authorFalivene, Laura
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorCavallo, Luigi
dc.contributor.authorCazin, Catherine S. J.
dc.contributor.authorNolan, Steven P.
dc.date.accessioned2015-08-03T09:45:26Z
dc.date.available2015-08-03T09:45:26Z
dc.date.issued2012-03-13
dc.identifier.citationChartoire, A., Lesieur, M., Falivene, L., Slawin, A. M. Z., Cavallo, L., Cazin, C. S. J., & Nolan, S. P. (2012). [Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre-catalyst for the Preparation of Tetra-ortho-substituted Biaryls by Suzuki-Miyaura Cross-Coupling. Chemistry - A European Journal, 18(15), 4517–4521. doi:10.1002/chem.201104009
dc.identifier.issn09476539
dc.identifier.doi10.1002/chem.201104009
dc.identifier.urihttp://hdl.handle.net/10754/562127
dc.description.abstractThe bigger the better: The new well-defined [Pd(IPr*)(cin)Cl] pre-catalyst is described (see scheme). This complex proves to be highly active in the Suzuki-Miyaura cross-coupling for the synthesis of tetra-ortho- substituted biaryls under mild conditions. IPr* is reported as the largest N-heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.sponsorshipWe gratefully acknowledge the EC for funding through the seventh framework programme SYNFLOW. We thank the EPSCR National Mass Spectrometry Service Center in Swansea for mass spectrometric analyses. Umicore AG is thanked for its generous gifts of materials. S.P.N. is a Royal Society Wolfson Research Merit Award holder. C.S.J.C. acknowledges the Royal Society for a University Research Fellowship.
dc.publisherWiley
dc.subjectbiaryls
dc.subjectcross-coupling
dc.subjectN-heterocyclic carbenes
dc.subjectpalladium
dc.title[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalChemistry - A European Journal
dc.contributor.institutionEaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, United Kingdom
dc.contributor.institutionDipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy
kaust.personCavallo, Luigi
dc.relation.issupplementedbyDOI:10.5517/ccxsr8p
display.relations<b> Is Supplemented By:</b> <br/> <ul><li><i>[Dataset]</i> <br/> Chartoire, A., Lesieur, M., Falivene, L., Slawin, A. M. Z., Cavallo, L., Cazin, C. S. J., & Nolan, S. P. (2012). CCDC 857933: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccxsr8p. DOI: <a href="https://doi.org/10.5517/ccxsr8p">10.5517/ccxsr8p</a> HANDLE: <a href="http://hdl.handle.net/10754/624668">10754/624668</a></li></ul>
dc.date.published-online2012-03-13
dc.date.published-print2012-04-10


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