[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling
Type
ArticleAuthors
Chartoire, AnthonyLesieur, Mathieu
Falivene, Laura
Slawin, Alexandra M. Z.
Cavallo, Luigi
Cazin, Catherine S J
Nolan, Steven P.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionKAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
Date
2012-03-13Metadata
Show full item recordAbstract
The bigger the better: The new well-defined [Pd(IPr*)(cin)Cl] pre-catalyst is described (see scheme). This complex proves to be highly active in the Suzuki-Miyaura cross-coupling for the synthesis of tetra-ortho- substituted biaryls under mild conditions. IPr* is reported as the largest N-heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Sponsors
We gratefully acknowledge the EC for funding through the seventh framework programme SYNFLOW. We thank the EPSCR National Mass Spectrometry Service Center in Swansea for mass spectrometric analyses. Umicore AG is thanked for its generous gifts of materials. S.P.N. is a Royal Society Wolfson Research Merit Award holder. C.S.J.C. acknowledges the Royal Society for a University Research Fellowship.Publisher
Wiley-BlackwellJournal
Chemistry - A European JournalISSN
09476539Handle URI
http://hdl.handle.net/10754/562127Is Supplemented By
Chartoire, A., Lesieur, M., Falivene, L., Slawin, A. M. Z., Cavallo, L., Cazin, C. S. J., & Nolan, S. P. (2012). CCDC 857933: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccxsr8pDOI:10.5517/ccxsr8p
HANDLE:http://hdl.handle.net/10754/624668