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    A planar conducting micro-loop structure for transportation of magnetic beads: An approach towards rapid sensing and quantification of biological entities

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    Type
    Article
    Authors
    Gooneratne, Chinthaka Pasan
    Giouroudi, Ioanna
    Kosel, Jürgen cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Date
    2012-03-01
    Permanent link to this record
    http://hdl.handle.net/10754/562122
    
    Metadata
    Show full item record
    Abstract
    Magnetic beads are utilized effectively in a wide variety of medical applications due to their small size, biocompatibility and large surface to volume ratio. Microfluidic lab-on-a-chip (LOC) devices, which utilize magnetic beads, are promising tools for accurate and rapid cell sorting and counting. Effective manipulation of beads is a critical factor for the performance of LOC devices. In this paper we propose a planar conducting micro-loop structure to trap, manipulate and transport magnetic beads. Current through the micro-loops produces magnetic field gradients that are proportional to the force required to manipulate the beads. Numerical analyses were performed to study the magnetic forces and their spatial distributions. Experimental results showed that magnetic beads could not only be transported towards a target region, e.g., for sensing purposes, but also the trapping rate could be increased by switching current between the different loops in the micro-loop structure. This method could lead to rapid and accurate quantification of biological entities tagged with magnetic beads. Copyright © 2012 American Scientific Publishers. All rights reserved.
    Publisher
    American Scientific Publishers
    Journal
    Sensor Letters
    DOI
    10.1166/sl.2012.2583
    ae974a485f413a2113503eed53cd6c53
    10.1166/sl.2012.2583
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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