Synthesis of 3-fluoro-3-aryl oxindoles: Direct enantioselective α arylation of amides

Abstract
Modus operandi: Catalytic access to the title compounds through a new asymmetric α-arylation protocol is reported (see scheme). These products are formed in good yields and excellent enantioselectivities by using a new and easily synthesized chiral N-heterocyclic carbene (NHC) ligand. Advanced DFT calculations reveal the properties of the NHC ligand and the mode of operation of the catalyst. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation
Wu, L., Falivene, L., Drinkel, E., Grant, S., Linden, A., Cavallo, L., & Dorta, R. (2012). Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides. Angewandte Chemie International Edition, 51(12), 2870–2873. doi:10.1002/anie.201200206

Publisher
Wiley

Journal
Angewandte Chemie

DOI
10.1002/anie.201200206

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